| 一氧化氮对海人酸诱导大鼠癫痫发作脑组织海马结构HSP70表达的影响及意义 |
| |
| 引用本文： | 崔荣太,李晓华,黄远桂. 一氧化氮对海人酸诱导大鼠癫痫发作脑组织海马结构HSP70表达的影响及意义[J]. 立体定向和功能性神经外科杂志, 2001, 14(1): 17-18 |
| |
| 作者姓名： | 崔荣太 李晓华 黄远桂 |
| |
| 作者单位： | 1. 青岛儿童医院儿保科
2. 第四军医大学西京医院神经内科 |
| |
| 摘 要： | 目的：研究海人酸诱导大鼠癫痫发作脑组织中一氧化氮（NO）与热休克蛋白70（HSP70）表达的关系。方法：利用免疫印迹分析法（westem blots)观察海人酸诱导大鼠癫痫发作及作用N－硝基－左旋精氨酸（LNNA）干预后脑组织海马结构HSP70的表达。结果：在癫痫发作过程中，预先用LNNA后，HSP70表达量较同一时间未干预的明显低。结论：在癫痫发作过程中，NO对HSP70表达有明显影响。
|
| 关 键 词： | 癫痫 热休克蛋白70 一氧化氮 免疫印迹分析 |
| 修稿时间： | 2001-01-11 |
Effect and meaning of NO on HSP70 in the hippocampus of rat brain during kainic acid-induced seizures |
| |
| Cui Rongtaik,Li Xiaohua,Huang Yuangui. Effect and meaning of NO on HSP70 in the hippocampus of rat brain during kainic acid-induced seizures[J]. Chinese Journal of Stereotactic and Functional Neurosurgery, 2001, 14(1): 17-18 |
| |
| Authors: | Cui Rongtaik Li Xiaohua Huang Yuangui |
| |
| Affiliation: | Cui Rongtaik,Li Xiaohua,Huang Yuangui.Department of Neurology,PLA 401 Hospital,Qingdao 266071 |
| |
| Abstract: | Objective:To study the role of nitric oxide(NO) effecting on heat shock protein 70(HSP70) in the epileptic seizures induced by kainic acid(KA).Methods:Western blotting method to observe the effect of LNNA on HSP70 expression in the hippocampus of rat brain following systemic adminstration of KA.Results:LNNA can inhibit HSP70 expression.Conclusion:NO influence HSP70 expression during epileptic seizures. |
| |
| Keywords: | Epilepsy Heat shock protein 70 Nitric oxide Western blots |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
