Surfactant protein D increases fusion of Mycobacterium tuberculosis-containing phagosomes with lysosomes in human macrophages |
| |
| Authors: | Ferguson J Scott Martin Jennifer L Azad Abul K McCarthy Travis R Kang Peter B Voelker Dennis R Crouch Erika C Schlesinger Larry S |
| |
| Affiliation: | Division of Infectious Diseases, Department of Internal Medicine, The Ohio State University, N-1147 Doan Hall, 410 W. 10th Avenue, Columbus, OH 43210, USA. |
| |
| Abstract: | Lung surfactant protein D (SP-D) binds to Mycobacterium tuberculosis surface lipoarabinomannan and results in bacterial agglutination, reduced uptake, and inhibition of growth in human macrophages. Here we show that SP-D limits the intracellular growth of bacilli in macrophages by increasing phagosome-lysosome fusion but not by generating a respiratory burst. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
