长链非编码RNA异常表达对急性髓系白血病预后影响的meta分析

目的　探讨长链非编码RNA（lncRNA）异常表达对急性髓系白血病（AML）预后的影响。方法　检索PubMed、Embase、Cochrane数据库截止2021年10月6日前发表的所有相关文献。结果　最终纳入13项研究，共1 591人。lncRNA异常表达与AML患者，尤其是与非-急性早幼粒细胞白血病［AML（non-M3）］患者的总体生存率（OS）降低有关，并与无复发生存率（RFS）降低有关。亚组分析显示HOX转录反义基因间RNA（HOTAIR）和牛磺酸上调基因1（TUG1）的高表达与较差的OS相关。结论　lncRNA的异常表达与AML患者不良预后显著相关，其异常表达是AML患者预后不良的危险因素，可以作为预测AML患者预后的生物标志物。

Meta analysis of the effect of abnormal expression of long noncoding RNAon the prognosis of acute myeloid leukemia

Objective　To investigate the effect of abnormal expression of long noncoding RNA(lncRNA) on the prognosis of acute myeloid leukemia (AML). Method　All relevant literatures published before October 6, 2021 in PubMed,Embase, and Cochrane databases were searched. Results　A total of 1 591 people were included in 13 studies. The abnormalexpression of lncRNA was related to the reduction of overall survival (OS) inpatients with AML, especially in patients with non-acute promyelocytic leukemia[AML (non-M3)], and to the reduction of recurrence free survival (RFS).Subgroup analysis showed that high expression of HOTAIR and taurine-upregulatedgene 1 (TUG1) was associated with poor OS. Conclusion　The abnormal expression of lncRNA is significantly correlated with thepoor prognosis in AML patients, its abnormal expression is a risk factor forthe poor prognosis in AML patients, and it can be used as a biomarker topredict the prognosis in AML patients.