小牛血去蛋白提取物滴眼液对佩戴角膜塑形镜青少年近视患者眼表情况的改善效果

目的 探讨小牛血去蛋白提取物滴眼液对佩戴角膜塑形镜青少年近视患者眼表情况的改善效果及安全性。设计 病例对照研究。 研究对象 选取并采用随机数字表法将2018年1月至2021年1月绍兴市中心医院收治的需佩戴角膜塑形镜的青少年近视患者116例（232眼），分为对照组（58例116眼）和观察组（58例116眼）。方法 对照组常规佩戴角膜塑形镜，观察组在此基础上于白天使用小牛血去蛋白提取物滴眼液（1滴/眼，4次/天），比较两组治疗前及治疗1个月后裸眼视力、屈光度、眼轴长度、角膜曲率、角膜表面规则指数（SRI）、泪膜破裂时间（BUT）、泪膜脂质层厚度（LLT）以及结膜充血、高眼压、畏光不适及角膜上皮着染等并发症的发生率。主要指标 裸眼视力、屈光度、眼轴长度、角膜曲率、SRI、BUT、LLT以及并发症。结果 与治疗前相比，两组治疗后裸眼视力、屈光度明显改善，角膜曲率明显降低，SRI水平明显升高（P均<0.05），且两组间裸眼视力、屈光度、眼轴长度、角膜曲率、SRI水平均无明显差异（P均>0.05）。与治疗前相比，治疗后两组BUT、LLT水平均明显降低（P均<0.05），且观察组（7.34±2.10 s、60.52±10.84nm）明显高于对照组（6.26±2.03 s、55.20±11.73 nm）（P均<0.001）；治疗后，两组间结膜充血、高眼压、畏光不适发生率比较无明显差异（P均>0.05），观察组角膜上皮着染发生率（8.62%）明显低于对照组（24.14%）（P=0.024）。结论 佩戴角膜塑形镜的青少年近视患者辅助滴用小牛血去蛋白提取物滴眼液后，在不影响角膜塑形镜矫正效果的基础上可改善眼表情况。（眼科，2022, 31： 231-234）

Effect of calf blood deproteinized extract eye drops on improvement of ocular surface in adolescents wearing orthokeratology lenses

Objective To investigate the efficacy and safety of deproteinized calf blood deproteinized extract eye drops on ocular surface conditions in adolescent myopic patients wearing orthokeratology lenses. Design Case-control study. Participants A total of 116 adolescent myopic patients (232 eyes) wearing orthokeratology lenses admitted to Shaoxing Central Hospital from January 2018 to January 2021 were selected and randomly divided into the control group (58 cases, 116 eyes) and the observation group (58 cases, 116 eyes). Methods The control group wore orthokeratology lenses in routine and the observation group used calf blood deproteinized extract eye drops during the day on the basis (1 drop/eye, 4 times/day). The uncorrected visual acuity (UCVA), diopter and axial length, corneal curvature, corneal surface regularity index (SRI), tear break-up time (BUT), tear film lipid layer thickness (LLT), conjunctivitis, ocular hypertension, photophobia discomfort and the incidence of corneal epithelial staining complications were compared between the two groups after 1 month of treatment. Main Outcome Measures UCVA, diopter and axial length, corneal curvature, SRI, BUT, LLT, and complications. Results Compared with before treatment, the UCVA and diopter of the two groups were apparently improved after treatment, the corneal curvature was apparently reduced, and the SRI level was apparently increased (all P<0.05). There was no significant difference in UCVA, diopter, axial length, corneal curvature and SRI level between the two groups after the treatment (all P>0.05). Compared with before treatment, the levels of BUT and LLT in the two groups were apparently decreased after treatment (P<0.05), and the observation group (7.34±2.10) s, (60.52±10.84) nm] was apparently higher than those in the control group (6.26±2.03) s, (55.20±11.73) nm] (all P<0.001); after treatment, there was no significant difference in the incidences of conjunctivitis, high intraocular pressure and photophobia between the two groups (all P>0.05). The incidence of corneal epithelial staining (8.62%) was apparently lower than that of the control group (24.14%) (P=0.024). Conclusion The ocular surface condition can be improved after auxiliary instillation of calf blood deproteinized extract eye drops in adolescent myopic patients who wear orthokeratology lenses without affecting the correction effect of orthokeratology lenses. (Ophthalmol CHN, 2022, 31: 231-234)