维生素D缺乏与围生期抑郁症的相关性

维生素D（Vitamin D,VD）作为孕产期所必需的营养素之一,其不仅与骨代谢有关,而且具有影响脑内神经免疫调节、神经营养因子和神经传递在内的多重神经活性。近年研究发现,VD对抑郁症的发生有不同程度的影响。而产前和产后抑郁症作为抑郁症的分支,其与VD的关系也备受关注。VD缺乏不仅可能导致复发性流产、妊娠期糖尿病和子痫前期等,还与妊娠期和产后的抑郁症状有关。有文献报道VD缺乏可能是围生期抑郁症的重要危险因素之一。围生期合理补充VD对抑郁症有一定的防治作用,但对于VD补充的时机和剂量还需要更多的研究证实。结合近年发表的国内外文献,探讨VD缺乏与围生期抑郁症之间的相关性,以期为疾病的早期预防、早期诊断和及时治疗提供理论依据,并为后期的研究提供新思路。

Correlation between Vitamin D Deficiency and Perinatal Depression

Vitamin D (VD) is one of the essential nutrients in pregnancy and perinatal period. It is not only related to bone metabolism, but also has multiple neural activities affecting neuroimmune regulation, neurotrophic factors and neurotransmission in the brain. Recent studies have found that VD has varying degrees of influence on the occurrence of depression. Prenatal and postnatal depression as a branch of depression, their relationship with VD is also being studied. VD deficiency can not only lead to recurrent spontaneous abortion, gestational diabetes and pre-eclampsia, but also be associated with depression symptoms during pregnancy and postpartum. It has been reported that VD deficiency may be one of the important risk factors for perinatal depression. Reasonable perinatal VD supplementation has a certain prevention and treatment effect on depression, but more studies are needed to confirm the timing and dose of VD supplementation. Combined with the domestic and foreign literatures published in recent years, we reviewed the correlation between VD deficiency and perinatal depression in this article, providing theoretical basis for early prevention, early diagnosis and timely treatment of the disease, and providing new ideas for later research.