多囊卵巢综合征鼠类动物模型的构建

多囊卵巢综合征（polycystic ovarian syndrome,PCOS）是育龄期女性常见的一种内分泌代谢性疾病,病因复杂,发病率高,其多样化的临床表现以及远期并发症严重影响女性的身心健康和生活质量。为了深入认识PCOS,构建一个实用有效的动物模型十分必要。由于大鼠和小鼠体型小,繁殖周期短,具有较稳定的动情周期,对于实验研究既经济又方便,是最常用的实验动物之一。对国内外学者基于PCOS的发病特点、激素水平、内分泌及代谢指标建立的PCOS鼠类模型的研究进展予以综述,旨在评价各种模型的优缺点,为实验中模型的选择提供指导。

Construction of Mouse Model of Polycystic Ovary Syndrome

Polycystic ovary syndrome（PCOS） is considered to be one of the most common female endocrine diseases with complex etiology and high incidence rate. Its diverse clinical manifestations and long-term complications seriously affect the physical and mental health and quality of life of patients. Therefore, the establishment of a practical and effective experimental model is very important to the research of PCOS. Rats and mice are one of the most commonly used experimental animals because of their small size, short reproductive cycle and stable estrous cycle. This paper reviews the research progress of mouse models of PCOS at home and abroad based on the clinical characteristics, hormone levels, endocrine and metabolic indexes of PCOS, aims to evaluate the advantages and disadvantages of various models and provide guidance for the selection of models in experiments.