| 结核病黏膜疫苗的研究进展北大核心CSCD |
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| 引用本文： | 王丽梅. 结核病黏膜疫苗的研究进展北大核心CSCD[J]. 中国人兽共患病杂志, 2022, 38(2): 170-174. DOI: 10.3969/j.issn.1002-2694.2022.00.020 |
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| 作者姓名： | 王丽梅 |
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| 作者单位： | 陕西省西安市空军军医大学基础医学院微生物与病原生物学教研室,西安 710032 |
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| 基金项目： | 陕西省重点研发计划(No.2019SF-090) |
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| 摘 要： | 呼吸道黏膜免疫是机体抵御结核分枝杆菌(Mycobacterium tuberculosis,MTB)感染的第一道防线,是重要的抗MTB感染的保护性免疫,如何通过黏膜免疫,诱导黏膜免疫系统产生抗MTB感染的特异性免疫,是目前结核病疫苗研究的新方向。本文基于近年来结核病黏膜疫苗的研究,总结了不同类型疫苗的特点、黏膜免疫后的免疫学特性和免疫保护效果,展望了未来结核病黏膜疫苗的研究方向,希望能够对研发更加高效的结核病黏膜疫苗有所启示。
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| 关 键 词： | 结核病 结核分枝杆菌 疫苗 黏膜免疫 |
| 收稿时间： | 2021-05-14 |
Development of tuberculosis mucosal vaccines |
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| WANG Li-mei. Development of tuberculosis mucosal vaccines[J]. Chinese Journal of Zoonoses, 2022, 38(2): 170-174. DOI: 10.3969/j.issn.1002-2694.2022.00.020 |
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| Authors: | WANG Li-mei |
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| Affiliation: | Department of Microbiology and Pathogenic Biology, School of basic Medicine, Air Force Medical University, Xi?an 710032, China |
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| Abstract: | Respiratory mucosal immunity, the host?s first line of defense against Mycobacterium tuberculosis (MTB) infection, plays an essential role in protecting against MTB infection. Mucosal immunization to induce specific immunity in the mucosal immune system has become a new research direction in the novel tuberculosis vaccine areas. On the basis of recent studies on tuberculosis mucosal vaccines, this article summarizes the characteristics of different types of vaccines, immunological features and protective effects against MTB infection. In addition, future prospects for research on mucosal vaccines of tuberculosis are described, to guide more effective studies. |
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| Keywords: | tuberculosis Mycobacterium tuberculosis vaccine mucosal immunization |
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