昼夜节律紊乱对女性卵巢功能的影响

昼夜节律是一种内源性的计时机制,可以调控人体所需的睡眠、饮食和生殖节律等。随着生活、工作模式的改变,昼夜节律紊乱已成为普遍关注的健康问题。卵巢功能反映卵巢皮质区基础卵泡生长发育的能力,包括卵泡的数量和质量,反映了女性的生育潜能。研究表明,昼夜节律与卵巢功能存在相关性。昼夜节律紊乱通过改变生殖激素的分泌、排卵、卵母细胞数量、褪黑素水平和时钟基因的表达影响卵巢功能。综述昼夜节律紊乱对卵巢功能的影响,为临床的研究及诊疗方向提供思路。

Effect of Circadian Rhythm Disorder on Ovarian Function

Circadian rhythm as an endogenous timing mechanism regulates the sleep, diet and reproductive rhythm of human body. With the changes of life and work patterns, the disorder of circadian rhythm has become a health problem of general concern. Ovarian function reflects the growth and development ability of basic follicles in ovarian cortex, including the number and quality of follicles, and reflects women′s reproductive potential. More and more studies have shown that there is a correlation between circadian rhythm and ovarian function. Circadian rhythm disorder affects ovarian function by changing the secretion of reproductive hormones, ovulation, the number of oocytes, the level of melatonin and the expression of clock genes. This review expounds the influence of circadian rhythm disorder on ovarian function, so as to provide ideas for clinical research and diagnosis and treatment.