| 辛伐他汀对介入术后急性冠状动脉综合征患者血清炎症因子的影响 |
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| 引用本文： | 彭城,冯建启,武维恒.辛伐他汀对介入术后急性冠状动脉综合征患者血清炎症因子的影响[J].岭南心血管病杂志,2008,14(3):174-176. |
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| 作者姓名： | 彭城 冯建启 武维恒 |
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| 作者单位： | 徐州医学院第二附属医院心内科,江苏徐州,221006 |
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| 摘 要： | 目的观察辛伐他汀对介入治疗术后急性冠状动脉综合征患者炎症因子影响及讨论其临床意义。方法住院已行介入治疗单支病变的急性冠状动脉综合征97例，分为辛伐他汀40mg组、辛伐他汀20mg组和对照组，正常组为20名健康成人；测定治疗前、治疗4周后可溶性细胞黏附分子-1、血浆基质金属蛋白酶-9及C反应蛋白水平。结果用药4周后，辛伐他汀40mg组及辛伐他汀20mg组的可溶性细胞黏附分子-1、血浆基质金属蛋白酶-9及C反应蛋白水平均较对照组低（P〈0．01）．而辛伐他汀40mg组较辛伐他汀20mg组更低（P〈0．05）。结论辛伐他汀可减轻介入治疗急性冠状动脉综合征患者的炎症反应；高剂量辛伐他汀抗炎效果更强。
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| 关 键 词： | 急性冠状动脉综合征 介入治疗 辛伐他汀 细胞黏附分子 可溶性 C反应蛋白 基质金属蛋白酶 |
Effect of simvastatin on inflammatory factor serum levels in patients with acute coronary syndrome after percutaneous coronary intervention |
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| PENG Cheng,FENG Jian-qi,WU Wei-heng.Effect of simvastatin on inflammatory factor serum levels in patients with acute coronary syndrome after percutaneous coronary intervention[J].South China Journal of Cardiovascular Diseases,2008,14(3):174-176. |
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| Authors: | PENG Cheng FENG Jian-qi WU Wei-heng |
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| Institution: | PENG Cheng,FENG Jian-qi,WU Wei-heng(Department of Cardiology,The Second Affiliated Hospital,Xuzhou Medical College,Xuzhou Jiangsu 221006,China) |
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| Abstract: | Objectives To observe effects of simvastatin on plasma levels solubility intercellular adhesion molecule-1(sICAM-1),matrix metalloproteinase-9(MMP-9) and C-reactive profein(CRP) in patients of acute coronary syndrome(ACS) after percutaneous coronary intervention(PCI) and clinical significance.Methods Patients with ACS after PCI were randomly assigned into three groups: one group treated with simvastatin 40 mg/d,another group treated with simvastatin 20 mg/d,while the control group without treated with simva... |
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| Keywords: | Acute coronary syndrome Percutaneous coronary intervention Simvastatin Solubility intercellular adhesion molecule-1 C-reactive protein Matrix metalloproteinases-9 |
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