补肾壮骨汤治疗膝关节骨性关节炎的效果研究

目的探讨补肾壮骨汤治疗膝关节骨性关节炎的临床效果，以期为临床治疗提供依据。方法选择2011年2月～2013年4月本院收治的膝关节骨性关节患者87例，根据随机数表分为对照组和观察组。对照组给予洛索洛芬钠片治疗，观察组给予自拟补肾壮骨汤治疗，两组患者在上述治疗基础上给予功能锻炼。观察两组患者治疗前后膝关节疼痛、晨僵和关节活动度评分，临床疗效及不良反应发生率。结果两组患者治疗后疼痛、晨僵、关节活动度评分及总分明显低于治疗前，差异有统计学意义（P〈O．05）；观察组患者疼痛、晨僵、关节活动度评分及总分低于对照组，差异有统计学意义（P〈O．05）。对照组和观察组患者治疗后总有效率分别为71．43％和93．33％，差异有统计学意义（P〈O．05）。对照组患者上腹疼痛发生率为23．81％、呕吐发生率为16．67％、转氨酶升高发生率为9．52％、皮疹发生率为7．14％；观察组患者无一例发生不良反应。结论补肾壮骨汤治疗膝关节骨性关节炎具有较好的临床效果和安全性。

Effect study of bushen zhuanggu decoction in the treatment of knee os- teoarthritis

Objective To explore effect of bushen zhuanggu decoction in the treatment of knee osteoarthritis in order to provide basis for clinical treatment.Methods Eighty-seven eases of patient with knee osteoarthritis in our hospital from February 2011 to April 2013 were selected and divided into control group and observation group according to the ran- dom number table,control group was treated with loxoprofen sodium while observation group was treated with bushen zhuanggu decoction,and two groups were given functional exercise on the basis of treatment.The score of pain,morning stiffness and joint activity of two groups were assessed before and after treatment,clinical effect and the incidence rate of adverse reaction in two groups were compared.Results The score of pain,morning stiffness,joint activity and total score in two groups after treatment were significantly lower than before treatment,with statistical differenee（P〈0.O5）.The score of pain,morning stiffness,joint activity and total score in observation group were significantly lower than that in control group,with statistical differenee（P〈0.05）.The total effect rate of control group and observation group was 71.43% and 93.33% respectively after treatment,with statistical difference （P〈O.05）.The incidence rate of epigastrie pain,vomit- ing,transaminases elevated and rash in control group was 23.81%,16.67%,9.52% and 7.14% respectively,and there was no case of adverse reaction in observation group.Conclusion Clinical effect and safety of bushen zhuanggu decoction in the treatment of knee osteoarthritis were better.