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Cyanide loss from tissue baths in the presence and absence of tissue |
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| Authors: | Casey P Robinson Steven I Baskin William A Groff David R Franz |
| Institution: | 1. Pharmacodynamics and Toxicology, University of Oklahoma, Health Sciences Center, Oklahoma City, OK 73190, U.S.A.;2. United States Army Medical Research Institute of Chemical Defense, ATTN: SGRD-UV-YP, Aberdeen Proving Ground, MD 21010 U.S.A. |
| Abstract: | Loss of cyanide from Krebs-Henseleit solution (KHS) was studied in aerated tissue baths at 38°C in the presence and in the absence of tissue. The rate of cyanide loss was greater from 300-μM than from 30-μM solutions and still greater from 300-μM solutions in the presence of vascular tissue. Initial cyanide loss was much greater from the tissue-containing bath, and the half-time was shorter in the presence of tissue (54 min) than in its absence (98 min) in baths containing the same initial cyanide concentration (300 μM). |
| Keywords: | Cyanide loss from solution cyanide toxicokinetics cyanide in vitro KHS Krebs-Henseleit solution |
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