The absence of testicular atrophy and in vivo and in vitro effects on hepatocyte morphology and peroxisomal enzyme activities in male rats following the administration of several alkanols |
| |
Authors: | C Rhodes T Soames MD Stonard MG Simpson AJ Vernall CR Elcombe |
| |
Institution: | Imperial Chemical Industries PLC, Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire U.K. |
| |
Abstract: | Previous studies have shown that ethylhexanol (2-EH) and its oxidation products, but not n-hexanol, produce hepatomegaly, peroxisomal proliferation and hypotriglyceridaemia. In the present studies we have confirmed that at 1 mmol/kg doses, neither the linear nor branched chain alcohols induce testicular atrophy, hepatomegaly, peroxisome proliferation or hypolipidaemia. In vivo, neither the free alcohols nor their metabolic products seem to be responsible for the activity of the parent plasticiser. The released monoesters are probably the more potent metabolic products responsible for the hepatomegaly, peroxisomal proliferation and hypolipidaemia. This contention is supported by the in vitro hepatocyte data which demonstrate the induction of peroxisomal oxidative enzymes by MEHP whereas the alcohols were without effects. |
| |
Keywords: | Di(2-ethylhexyl)phthalate di(2-ethylhexyl)adipate 2-ethylhexanol peroxisome proliferation plasticiser alcohols sub-acute toxicity CN cyanide DEHA di-(2-ethylhexyl) adipate DEHP di-(2-ethylhexyl)phthalate 2-EH 2-ethyl hexanol MEHP mono-(2-ethylhexyl)phthalate |
本文献已被 ScienceDirect 等数据库收录! |
|