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The effect of aluminum on the metabolism of embryonic chick bone in tissue culture |
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| Authors: | Miyahara Tatsuro Hayashi Miyuki Kozuka Hiroshi |
| Affiliation: | Faculty of Pharmaceutical Sciences, Toyama Medical & Pharmaceutical University, 2630, Sugitani, Toyama-Shi, Toyama 930-01 Japan |
| Abstract: | The effect of aluminum (Al) on bone metabolism was assessed in organ cultures of embryonic chick bone. Al of 10?4 M and above caused an inhibitory effect on mineralization without inhibiting matrix formation and a stimulative effect on demineralization without stimulating matrix degradation. Therefore, Al was shown to influence the mineral metabolism of bone. |
| Keywords: | Aluminum mineralization bone formation tissue culture Hyp hydroxyproline PTH parathyroid hormone TCA trichloroacetic acid |
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