Levels of plasma-free fatty acids and liver triglycerides in rats treated with adrenaline or theophylline: effects exerted by administration of uridine diphosphate glucose

Adrenaline or theophylline administration to rats causes increased levels of plasma-free fatty acids and liver triglycerides; however, plasma FFA and liver triglyceride values are reduced in animals treated either with adrenaline or theophylline if they receive UDPG pretreatment. The protective effect exerted by UDPG in animals receiving the combined treatment is attributable to a decrease of cAMP-dependent lipolytic activity. Furthermore, the antilipemic lowering lipid effect exhibited by UDPG is linked to the intact nucleotide molecule, because compounds structurally associated to UDPG, like uridine, UMP, UDP or glucose- 1-phosphate, are incapable of affecting the increased lipolytic activity observed in adrenaline injected rats.