The fate of synaptic membranes of degenerating optic nerve terminals, and their role in the mechanism of trans-synaptic changes |
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Authors: | Henryk M Winiewski Bernardino Ghetti and Dikran S Horoupian |
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Institution: | (1) Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461 The Bronx, New York |
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Abstract: | Summary The fate of synaptic membranes of degenerating optic nerve terminals has been studied in the lateral geniculate nucleus of Rhesus monkey after eye enucleation. It was shown that pre-synaptic and post-synaptic membranes remain in close apposition to each other during all stages of degeneration and phagocytosis of affected terminals. As a result of this, fragments of presynaptic terminals were engulfed within glial processes, together with synaptic thickenings and parts of post-synaptic dendrites. On occasion small pieces of the degenerating terminals together with the synaptic membranes were engulfed by the post-synaptic dendrite. It is proposed that this pattern of removal of degenerating optic terminals results in injury to the post-synaptic cells, and triggers the transneuronal degeneration. |
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Keywords: | Lateral geniculate nucleus optic nerve terminals synaptic membranes post-synaptic dendrite phagocytosis trans-synaptic degeneration |
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