Alternating ventilation in a rat model of increased abdominal pressure |
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| Authors: | Cagido Viviane Ramos Zin Walter Araújo Ramirez José Navajas Daniel Farré Ramón |
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| Affiliation: | a Laboratory of Respiratory Physiology, Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil;b Departament d’Anatomia Patologica, Hospital Clinic, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain;c Unitat de Biofisica i Bioenginyeria, Facultat de Medicina, Universitat de Barcelona – IDIBAPS, Barcelona, Spain;d CIBER de Enfermedades Respiratorias, Bunyola, Spain;e Institut de Bioenginyeria de Catalunya, Barcelona, Spain |
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| Abstract: | During alternating ventilation (AV) one lung is inflating while the other is deflating. Considering the possible respiratory and hemodynamic advantages of AV, we investigated its effects during increased intra-abdominal pressure (IAP=10 mmHg). In Sprague-Dawley rats (n=6, 270-375g) the main bronchi were independently cannulated, and respiratory mechanics determined while animals underwent different ventilatory patterns: synchronic ventilation without increased IAP (SV-0), elevated IAP during SV (SV-10), and AV with elevated IAP (AV-10). Thirty-three other animals (SV-0, n=10; SV-10, n=11 and AV-10, n=12) were ventilated during 3h. Mean arterial pressure (MAP), and lung histology were assessed. Increased IAP resulted in significantly higher elastances (p<0.001), being AV-10 lower than SV-10 (p<0.020). SV-10 showed higher central venous pressure (p<0.003) than S-0; no change was observed in AV-10. Wet/dry lung weight ratio was lower in AV-10 than SV-10 (p=0.009). Application of AV reduced hemodynamic and lung impairments induced by increased IAP during SV. |
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| Keywords: | Alternating ventilation Respiratory mechanics Intra-abdominal pressure Hemodynamic Mechanical ventilation Animal model |
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