静脉应用不同剂量氯胺酮预防瑞芬太尼痛觉过敏的研究

目的 观察不同剂量氯胺酮静脉术前给药对瑞芬太尼产生超敏现象的预防效果.方法 全麻下行妇产科腹腔镜手术60例,随机分为3组,每组20例,分别在手术切皮前静注生理盐水2 ml(Ⅰ组),氯胺酮0.25 mg/kg(Ⅱ组),氯胺酮0.5 mg/kg( Ⅲ组).在拔管后、离室前以及术后1、2、4、8、12、24 h,采用VAS评...

Investigation of the effect of ketamine injected preoperatively on preventing remifentanit-induced hyperalgesia

Objective To investigate the effect of ketamine injected preoperatively on preventing remifentanil-induced hyperalgesia.Methods A total of 60 patients scheduled for receiving ketamine procedure under general anesthesia were randomly divided into three groups(n=20).2 ml normal saline,0.25 mg/kg and 0.5 mg/kg tramadol was intravenously injected before anesthesia in Groups Ⅰ,Ⅱand Ⅲ,respectively.Visual analog scale(VAS) pain save and Ramsay Sedation score were measured at postoperative 1,2,4,8,12 and 24 h,respectively.Adverse effects were also recorded.Results The VAS save was significantly lower within postoperative 8 hours in Groups Ⅱ and Ⅲ than that in GroupⅠ,while no significant difference was found among Groups Ⅱ and Ⅲ at each time point.Incidence of postoperative dysphoria,dizziness,nausea was higher in Groups Ⅱ and Ⅲ than that in Group Ⅰ,but there was no significant difference among the three groups.Conclusion Preoperative injection of 0.25-0.5 mg/kg ketamine prevents the development of remifentamil-induced hyperalgesia and reduces incidence of side effects.