潮州地区人乳头瘤病毒型别分布特征分析

目的研究潮州地区人乳头瘤病毒（HPV）感染率及型别分布特征,确定本地区的优势型别。方法采用实时荧光定量PCR和核酸分子快速导流杂交分型技术（HybriMax）对49458名参加新农村合作医疗＂宫颈癌筛查项目＂的妇女进行HR-HPV检测及分型来筛查宫颈癌。结果潮州地区妇女HR-HPV感染率为8.25%,15种高危亚型（HR-HPV）阳性率94.49%,6种低危亚型（LR-HPV）阳性率5.51%,感染率最高亚型是HPV52（28.86%）,其次为16、58、68、33和18型,均为HR-HPV。LR-HPVCP8304感染率是4.71%。结论本地区人群感染HPV优势型别为HPV52。

Analysis of subtypes distribution of human papilloma virus in Chaozhou area

Objective To investigate the infection rate of human papilloma virus （HPV）, distribution of HPV subtypes and to explicate the predominant subtype of HPV infection in Chaozhou area. Methods Real-time fluorescent quantitative PCR and HybriMax were adopted to detect subtypes of HR-HPV among 49458 women who participated in the new rural cooperative medical system on undergoing cervical carcinoma screening. Results The infection rate of HR-HPV among these women was 8.25%. The positive rate of the 15 high risk subtypes （HR-HPV） and that of the 6 low risk subtypes （LR-HPV） was 94.49% and 5.51%, respectively. The predominant subtype was HPV52（28.86%）, followed by the subtypes of 16, 58, 68, 33 and 18, which belong to HR-HPV. The infection rate of LR-HPV CP8304 was only 4.71%. Conclusion The predominant subtype of HPV infection was HPV52 in Chaozhou area.