2型糖尿病患者颈动脉内膜中层厚度与血清超敏C反应蛋白及餐后高脂血症的关系研究

【目的】探讨2型糖尿病（T2DM）患者颈动脉内膜中层厚度（CAIMT）与血清超敏c反应蛋白（CRP）及餐后高脂血症的关系及T2DM早期动脉硬化的机制。【方法】选取确诊T2DM患者201例，按CAIMT分为CAIMT增厚组（CAIMT〉0．9mm）103例及CAIMT正常组（CAIMT〈0．9ram）98例，另选100例健康者为对照组，均进行脂负荷餐，采集空腹及餐后4h的血标本，测定其血清超敏c反应蛋白（hs—CRP），测定空腹血糖（FBG），空腹及餐后4h甘油三酯（4hTG）。使用彩色多普勒测定各组受试者的CAIMT。【结果】①T2DM组血清hs—CRP、4hTG显著高于对照组（P〈0．01），T2DM组中CAIMT增厚组hs—CRP、4hTG显著高于cAIMT正常组（P〈0．01）。②T2DM患者hs—CRP、4hTG与CAIMT均呈正相关（P〈0．01），hs—CRP与4hTG也相关（P〈0．01）。【结论】血清hs—CRP及餐后高脂血症与T2DM患者早期动脉硬化有密切的关系。

Study on the Relationship of Carotid Intima-media Thickness with Serum High-sensitive C-reactive Protein and Postprandial Hyperlipidemia in Type 2 Diabetes Mellitus

Objective] To explore the relationship of carotid intima-media thickness（CAIMT） with serum high-sensitive C-reactive protein（CRP） and postprandial hyperlipidemia in patients with type 2 diabetes mellitus（T2DM） so as to investigate the mechanism of early atherosclerosis in T2DM. fMethods] Totally 201 T2DM patients were chosen. According to CAIMT, all patients were divided into CAIMT increased group （CAIMT〉0.9mm, n = 103） and normal CAIMT group（CAIMT〈0.9mm, n = 98）. Other 100 healthy people were chosen as the control group. Fat-load meal was given for all groups. Fasting and 4h-postprandial blood samples were collected. Serum high-sensitive CRP, blood-fasting glucose, fasting and 4h-postprandial triglyceride（4hTG） were measured. Color Doppler ultrasound was used to measure CAIMT of all subjects. Results] Serum high-sensitive CRP and 4hTG in T2DM groups were significantly higher than those in control group（ P〈0.01）. High-sensitive CRP and 4hTG in CAIMT increased group of T2DM group were significantly higher than those in CAIMT normal group（ P〈0.01）. High-sensitive CRP and 4hTG in T2DM patients were posi- tively related with CAIMT（ P〈0. 01, P〈0. 01）. High-sensitive CRP was also related with 4hTG（ P〈0.01）. Conclusion] Serum high sensitive CRP and postprandial hyperlipidemia may be closely correlated with early atherosclerosis in T2DM patients.