左旋甲状腺素对良性甲状腺结节的疗效及相关因素分析 |
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引用本文: | 刘玥,龚玮琦,邵莉,陈巍,江华. 左旋甲状腺素对良性甲状腺结节的疗效及相关因素分析[J]. 医学临床研究, 2012, 29(3): 399-401 |
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作者姓名: | 刘玥 龚玮琦 邵莉 陈巍 江华 |
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作者单位: | 刘玥 (上海市同济大学附属东方医院老年医学科,上海,200120) ; 龚玮琦 (上海市同济大学附属东方医院老年医学科,上海,200120) ; 邵莉 (上海市同济大学附属东方医院老年医学科,上海,200120) ; 陈巍 (上海市同济大学附属东方医院老年医学科,上海,200120) ; 江华 (上海市同济大学附属东方医院老年医学科,上海,200120) ; |
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基金项目: | 浦东新区卫生系统重点学科建设资助 |
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摘 要: | 【目的】评价左旋甲状腺素(L-T4)抑制性治疗对良性甲状腺结节的疗效及影响疗效的相关因素。【方法】选取良性甲状腺结节患者154例,随机分为L-T4治疗组和空白对照组,接受L-T4治疗或随访观察。随访12个月后,对两组的结节直径变化情况和相关的参数进行评价。【结果】L-T4治疗组甲状腺结节最大横截面直径缩小(-2.95±2.76)mm;而对照组结节最大横截面直径增大(2.02±2.84)mm,(P=0.001)。相关性分析显示:治疗组中,结节直径的变化与起始的结节直径及年龄呈负相关。【结论】L-T4是治疗良性甲状腺结节一种有效的治疗手段,能够有效的抑制良性甲状腺结节的生长。其疗效与起始结节直径及患者年龄相关。
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关 键 词: | 甲状腺结节/药物疗法 甲状腺素/治疗应用 |
Efficacy of Levothyroxine for the Treatment of Benign Thyroid Nodule and Its Correlative Factors |
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Affiliation: | LIU Yue, GONG Wei-qi, SHAO Li,et al (Department of Geriatrics, Shanghai Dongfang Hospital of Tongji University, Shanghai 200120, China ) |
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Abstract: | [Objective] To evaluate the efficacy of levothyroxine(L-T4 ) suppressive therapy for benign thyroid nodule and its correlative factors. [Methods] A total of 154 patients with benign thyroid nodule were chosen. All patients were randomly divided into L-T4 treatment group and control group. After 12 months of follow up, the change of the nodule diameter and the correlative parameters in 2 groups were evaluated. [Results] The diameter of maximal nodule cross section in L-T4 treatment group decreased(2. 95±2. 76mm), while that in control group increased(2. 025±2.84, P =0. 001). The correlative analysis showed that the nodule diameter in treatment group had negative correlation with original nodule diameter and patients age. [Conclusion] L-T4 suppressive therapy is an effective therapy. It can efficiently inhibit the growth of benign thyroid nodule. The efficacy is related to the original nodule diameter and patients age. |
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Keywords: | Thyroid nodule/DT thyroxine/TU |
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