原发性高血压患者血清内皮脂肪酶与脂联素水平的相关性研究

【目的】探讨原发性高血压（essentialhypertension，EH）患者与健康人血清脂肪细胞因子内皮脂肪酶（EL）和脂联素（APN）水平及两者之间的相关性。【方法】选取EH患者68例和健康人30例，用酶联免疫吸附法测定两组血清EL和APN的水平。【结果】EH患者血清EL水平显著高于健康对照组[（409．11±35．35）μg／Lvs（319．78＋17．31）μg／L（P〈O．01）]；而APN水平显著低于健康对照组E（5．13土0．59）mg／Lvs（8．36土0．30）mg／L（P〈O．01）]；②经多元线性回归分析显示，EH患者血清EL水平与收缩压呈显著正相关（r-0．380，P-0．002）；与APN水平呈负相关（r：平升高；②EH患者EL水平与收缩压呈正相关，而与-0．282，P-0．025）。【结论】①EH患者血清EL水APN水平呈负相关。

Study on the Relationship Between Serum Endothelial Lipase and Adiponectin in Patients with Essential Hypertension

[Objective] To explore the relationship between serum endothelial lipase（EL） and adiponectin（APN） in patients with essential hypertension（EH）. [Methods]Serum levels of EL and APN in 68 EH patients and 30 healthy controls were determined by enzyme linked immune sorbent assay. [Resultsl Serum EL level in EH patients was greatly higher than that in healthy controls[（409.11 ＋ 35.35）μg/L vs （319.78 4-17. 31）μg/L（ P 〈0.01）], while serum APN level in EH patients was greatly lower than that in healthy controls[（5.13~0.59）mg/L vs （8. 36 ＋ 0. 30）rng/L（ P 〈0, 01）]. Multiple linear regression analysis showed that serum EL level in EH patients was posi- tively correlated with systolic pressure（r= 0. 380, P = 0. 002） and negatively correlated with APN（r=- 0. 282, P = 0. 025）. [Conclusion]Serum EL level in EH patients increases. Serum EL level in EH patients is positively correlated with systolic pressure and negatively correlated with APN.