重组人生长激素治疗青春期前特发性矮小症60例疗效分析

【目的】探讨重组人生长激素（recombinant human growth hormone，rhGH）对青春期前特发性矮小症（Idiopathic short stature，ISS）儿童促身高增长的疗效。【方法】经胰岛素和左旋多巴药物联合激发试验测定生长激素（GH）确诊缺乏的ISS儿童60例，每晚睡前皮下注射rhGH治疗0．15IU／（kg．d），疗程6个月，并对其疗效进行一年的观察。【结果】ISS患儿经生长激素治疗后，生长速率（．growt h velocity，GV）由治疗前测量的（3．61士0．42）cm／年提高到治疗后（7．69±3．31）cm／年，差异有显著性（P〈0．05）。身高由治疗前（134．12±14．14）cm提高到治疗后（141．20±13．88）cm，差异有显著性（P〈0．05）。治疗期间除少数肝功能轻度异常，有6例儿童在注射部位出现一过性红肿，双下肢轻度水肿和过敏性皮疹等，但未予处理后自行消失，另未发现其他明显副作用。【结论】皮下注射rhGH对治疗儿童ISS有增快生长速度作用，疗效肯定，是一种安全有效的方法，值得儿科临床推广应用。

Analysis of the Efficacy of Recombinant Human Growth Hormone for the Treatment of Idiopathic Short Stature Before Puberty

Objective]To explore the effect of gene recombinant human growth hormone（rhGH） for improving the growth in stature in children with idiopathic short stature（ISS）. Methods] Sixty ISS children diagnosed by provocative test with insulin and levodopa for measuring growth hormone（GH） deficiency were given subcutaneous injection of rhGH 0.15IU/（kg. d） before sleep every night for 6 months. The efficacy was observed for a year. ResultsiAfter GH treatment for ISS children, the growth velocity（GV） increased from （3.61±0.42） cm/year before treatment to （7.69 ±3.31 ）cm/year after treatment, and there was significant difference（ P〈0.05）. The body height also increased from （ 134.12±14.14 ） cm before treatment to （ 141.20 ±13.88 ）cm after treatment, and there was significant difference（ P〈0.05）. During the treatment, a few patients had mildly abnormal liver function, and 6 patients had transient flare in the injection site, mild edema of both lower limbs and allergic skin rash, and these symptoms disappeared without treatment. Other obvious side effects were found. Conclusion] rhGH subcutaneous injection for the treatment of ISS children can improve the GV and has certain efficacy. Therefore it is a safe and effective method, and worthy of clinical applieation in pediatrics.