3岁以下哮喘患儿血清维生素D水平及其与肺功能的关系

【目的】探讨3岁以下哮喘儿童与维生素D水平其及与肺功能的关系。【方法】选取106例6个月至3岁哮喘患儿作为观察组；选取同期在儿童保健科体检的健康儿童82例为对照组。分别检测两组儿童血清25-（OH）-D。水平，并测定潮气呼吸肺功能。根据维生素D检测水平分类维生素D不足（〈50nmol／L）和维生素缺乏（〈25nmol／L）。【结果】观察组的维生素D缺乏、不足比例均高于对照组（x2-9．111，P-0．011）。观察组中维生素D缺乏者的气道重度阻塞率显著高于维生素D不足者和维生素D正常者，且随着25-（0H）-D。水平的逐渐降低，阻塞程度也不断加重（P〈O．01）。维生素D缺乏者的支气管舒张试验阳性率显著高于维生素D不足者和维生素D正常者，且随着25-（OH）-D。水平的逐渐降低，支气管舒张试验阳性率也逐渐增大（P〈0．05）。【结论】维生素D缺乏或不足与3岁以下儿童哮喘密切相关，25-（OH）-Ds水平与哮喘加重具有相关性，加重了小气道的阻塞程度，并可增加3岁以下儿童哮喘患儿的气道反应性。

Relationship Between Vitamin D and Asthma in Infants Below 3 Years Old

Objective] To explore the relationship between vitamin D（VitD） level and asthma in children below 3 years old. Methods] Totally 106 children with asthma aged 6 months to 3 years old were selected as the study group, meanwhile 82 healthy children were selected as the control group. Serum level of 25（OH）D2 in two groups was detec ted, and tidal breathing lung function was measured. Results] The proportion of VitD deficiency and insufficiency in the study group were higher than those in the control group（xz = 9. 111, P =0. 011）. The incidence of severe airway ob struction in children with VitD deficiency in the study group was significantly higher than that in children with VitD insuf ficiency or normal VitD. The exacerbation of severe obstructive lung disease increased with the gradual decreasing of the level of 25（OH）D3 （ P d0.01）. The positive rate of bronchial relaxation test in children with VitD deficiency was sig nificantly higher than that in children with VitD insufficiency or normal VitD, and increased with the gradual decreasing of the level of 25（OH）D3 （ P d0.05）. Conclusion]VitD deficiency or insufficiency is closely related to asthma in children below 3 years old. The level of 25 （OH）D3 is correlated with asthma exacerbation, and aggravates the small airway ob struction, and increases the airway responsiveness in children with asthma below 3 years old.