莫匹罗星对血透患者钝针扣眼穿刺后内瘘感染发生率的影响研究

目的 探讨莫匹罗星软膏对血透患者钝针扣眼穿刺技术动静脉内瘘感染发生率的影响.方法 经患者知情同意并签署知情同意书,并经医院伦理委员会批准后,将在本血液透析中心使用钝针扣眼穿刺的60例患者根据消毒方式的不同分为常规处理组(30例)和莫匹罗星处理组(30例).观察18个月后,比较2组患者动静脉内瘘感染、假性动脉瘤、内瘘狭窄等并发症发生情况.结果 常规处理组27例、莫匹罗星处理组29例进入观察终点.莫匹罗星处理组3例(10.34%)出现感染,均为轻度感染;常规处理组9例(33.33%)感染,其中5例(18.52%)轻度感染,4例(14.81%)重度感染.莫匹罗星组感染发生率明显低于常规处理组,差异有统计学意义(P<0.05).假性动脉瘤、内瘘狭窄发生率2组差异无统计学意义(P>0.05).结论 莫匹罗星有效降低血透患者钝针扣眼穿刺后内瘘感染发生率,特别是降低重度感染的发生率,并且未增加其他穿刺并发症的风险.

Effect of mupirocin prophylaxis on the incidence of infection following buttonhole cannulation in patients with hemodialysis

Objective To investigate whether mupirocin prophylaxis could reduce the incidence of infection following button -hole cannulation in patients with hemodialysis .Methods Sixty cases that received buttonhole cannulation in the Hemodialysis Centre of the hospital were divided in accordance with different treatment methods into the routine sterilization group and the mupirocin prophy -laxis group, each consisting of 30 cases.After 18-month observation, the incidence rates of infection caused by cannulation , false aneu-rysm and vascular stenosis were compared between the 2 groups.Results Twenty-seven cases in the routine sterilization group and 29 cases in the mupirocin prophylaxis group terminated the whole observation process .Three cases (10.34%) in the mupirocin prophylax-is group had mild infection, while in the routine sterilization group there were 9 cases of infection(33.33%), of which 5 had mild in-fection (18.52%) and 4 had severe infection (14.81%).The incidence of infection caused by cannulation in the mupirocin prophy -laxis group was significantly lower than that of the routine sterilization group (P<0.05).There were no statistical differences in the in-cidence of false aneurysm and vascular stenosis , when comparisons were made between the 2 groups(P>0.05).Conclusion Mupiro-cin prophylaxis could effectively reduce the rate of infection in patients with hemodialysis following buttonhole cannulation , the rate of severe infection in particular .Furthermore, it would not increase the risk of complications caused by other punctures .