妊娠期PM_(2.5)暴露与新生儿低出生体重的meta分析

目的定量分析和评价妊娠期PM_(2.5)暴露对新生儿低出生体重的影响。方法通过计算机联机检索国内外文献数据库,采用meta分析对妊娠期PM_(2.5)暴露与新生儿低出生体重关系的研究进行整合分析。经异质性检验后选择合适的效应模型进行统计量的计算合并,同时检验结果的稳健性及是否存在发表偏倚。结果最终筛选出16篇文献,meta分析结果显示,整个妊娠期PM_(2.5)暴露浓度每升高10μg/m~3,新生儿发生低出生体重的风险增加9.53%(95%CI:3.92%~14.84%);妊娠早、中、后期PM_(2.5)暴露浓度每升高10μg/m~3,新生儿发生低出生体重的风险分别增加6.77%(95%CI:-4.08%~17.40%),5.83%(95%CI:-2.02%~13.98%),2.96%(95%CI:-3.05%~9.53%)。敏感性分析发现,所获得的研究结果相对稳定可靠,但在分析整个妊娠期PM_(2.5)暴露对新生儿低出生体重的影响时仍存在一定的发表偏倚。结论整个妊娠期PM_(2.5)的暴露可能增加新生儿发生低出生体重的风险。

Association between maternal exposure to fine particulate matter and low birth weight:a meta analysis

Objective To quantitatively analyze and evaluate the association between maternal exposure to fine particulate matter (PM2.5) and low birth weight in newborns.Methods Domestic and international database were screened and metaanalysis was used to analyze the association between maternal exposure to PM2.5 and low birth weight.Estimations were pooled by random or fixed effect models according to the results of heterogeneity test;sensitivity analysis and publication bias analysis were also taken.Results A total of 16 studies were included in the meta-analysis at last.The results showed that a 10 μg/m3 increase in PM2.5 exposure during the entire duration of pregnancy was associated with a 9.53％ (95％CI:3.92％-14.84％)increase in low birth weight in newborns,while a 10 μg/m3 increase in PM2.5 exposure during the three different gestation periods were associated with 6.77％ (95％CI:-4.08％-17.40％),5.83％ (95％CI:-2.02％-13.98％),2.96％ (95％CI:-3.05％-9.53％) increase in low birth weight,respectively.Sensitivity analysis supported the results but publication bias was found for the analysis of the association between PM2.5 exposure during the entire duration of pregnancy and low birth weight.Conclusion PM2.5 exposure during the entire duration of pregnancy may increase the risk of low birth weight.