| 冬季重污染天气大气PM_(2.5)致突变性的初步研究 |
| |
| 引用本文： | 张少平,顾雯,治洪,张明,孔建,李毅民,徐东群. 冬季重污染天气大气PM_(2.5)致突变性的初步研究[J]. 环境与健康杂志, 2017, 34(7). DOI: 10.16241/j.cnki.1001-5914.2017.07.018 |
| |
| 作者姓名： | 张少平 顾雯 治洪 张明 孔建 李毅民 徐东群 |
| |
| 作者单位： | 中国疾病预防控制中心环境与健康相关产品安全所环境毒理室,北京,100021 |
| |
| 基金项目： | 国家卫生计生委卫生公益性行业科研专项 |
| |
| 摘 要： | 目的利用鼠伤寒沙门菌回复突变试验(Ames试验)测定冬季重污染天气下PM_(2.5)的致突变性。方法利用大流量采样器收集冬季优良天气及重污染天气PM_(2.5),PM_(2.5)全颗粒物剂量为100、250、500和1 000μg/皿,选用TA98菌株,采用平板掺入法进行Ames试验。结果优良天气下收集的PM_(2.5)在500、1 000μg/皿-S9剂量组及1 000μg/皿+S9剂量组致突变率(MR)2且有剂量-效应关系;严重污染天气下收集的PM_(2.5)在250、500和1 000μg/皿±S9剂量组MR2且有剂量-效应关系。结论 PM_(2.5)全颗粒物对TA98具有一定的致突变效应。
|
| 关 键 词： | PM2.5 Ames试验 致突变性 |
Preliminary study on mutagenicity of ambient PM2.5 in heavy pollution days in winter |
| |
| ZHANG Shao-ping,GU Wen,ZHI Hong,ZHANG Ming,KONG Jian,LI Yi-min,XU Dong-qun. Preliminary study on mutagenicity of ambient PM2.5 in heavy pollution days in winter[J]. Journal of Environment and Health, 2017, 34(7). DOI: 10.16241/j.cnki.1001-5914.2017.07.018 |
| |
| Authors: | ZHANG Shao-ping GU Wen ZHI Hong ZHANG Ming KONG Jian LI Yi-min XU Dong-qun |
| |
| Abstract: | Objective To explore the mutagenicity of PM2.5 by Salmonella typhimurium reversion mutation test (Ames test).Methods PM2.5 was collected by high volume sampler in sunny day and'heavy pollution'day in winter.The doses of the samples were 100,250,500 and 1 000 μg/plate for TA98 strains with/without metabolic activation system (S9).Results MR was ＞2 at 500 and 1 000 μg/plate (-S9) and 1 000 μg/plate (+S9) in sunny day and had a certain dose-response relationship.PM2.5 collected in'heavy pollution'day showed positive reaction at 250,500 and 1 000 μg/plate (±S9).Conclusion PM2.5 has a certain mutagenic effect to TA98. |
| |
| Keywords: | PM2.5 Ames test Mutagenicity |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
