环境双酚A暴露与人群糖尿病关系的meta分析

目的探讨环境双酚A(BPA)暴露与人群糖尿病的关系。方法以计算机检索中外期刊数据库[包括中国学术期刊全文数据库(CNKI)、万方数据知识服务平台全文数据库、维普中文科技期刊全文数据库(VIP)、Pub Med、EBSCO、Elsevier Science direct、Medical Evidence Matters Archive],收集各数据库从建库至2016年4月有关BPA暴露对糖尿病患病影响公开发表的文献。按照文献纳入排除标准筛选文献后进行meta分析。结果最终纳入9篇文献共10个研究。meta分析结果显示整体合并效应值OR为1.32(95%CI:1.15~1.52,P0.01);2型糖尿病、妊娠期糖尿病以及不区分糖尿病类型三组研究进行亚组分析,各自合并OR值分别为1.19(95%CI:0.99~1.42)、0.70(95%CI:0.27~1.79)以及1.80(95%CI:1.39~2.34),结合漏斗图和Egger回归分析(P=0.691)发现纳入文献不存在发表偏倚。结论较高BPA暴露可增加整体糖尿病的患病风险,但对不同类型糖尿病作用可能存在差异。

Relationship between BPA exposure and diabetes mellitus: a meta-analysis

Objective To explore the relationship between BPA exposure and the risk of diabetes.Methods CNKI,Wanfang databases,VIP,PubMed,EBSCO,Elsevier Science Direct,Medical Evidence Matters Archive were searched on line to collect the studies on the relationship between BPA exposure and the risk of diabetes published up to April 2016.The studies were screened according to inclusion and excluding criteria and then the meta-analysis was performed with software of Stata 12.0.Results A total of 9 literatures including 10 studies were included.The result of meta-analysis showed that the pooled odds ratio (OR) value was 1.32(95％CI:1.15-1.52,P＜0.01).The subgroup analysis of type 2 diabetes,gestational diabetes mellitus and all type of diabetes were performed respectively and the pooled ORs were 1.19 (95％CI:0.99-1.42),0.70 (95％CI:0.27-1.79) and 1.80 (95％CI:1.39-2.34).Combined with the funnel plot,no significant publication bias was found among the included studies by Egger regression (P=0.691).Conclusion Higher BPA exposure may increase the overall risk of diabetes,but the effect may not be the same for different types of diabetes.