| 铅神经毒性相关基因多态性的研究进展 |
| |
| 引用本文： | 申媛,吴学文,孙虹.铅神经毒性相关基因多态性的研究进展[J].环境与健康杂志,2017,34(2). |
| |
| 作者姓名： | 申媛 吴学文 孙虹 |
| |
| 作者单位： | 1. 中南大学湘雅医院肿瘤科,湖南长沙,410008;2. 中南大学湘雅医院耳鼻咽喉头颈外科 |
| |
| 基金项目： | 国家自然科学基金青年基金，国家重大科学研究计划，国家自然科学基金面上项目 |
| |
| 摘 要： | 长期铅暴露可对人体多个器官和系统造成损伤,其神经毒性效应尤为突出。在相同的铅暴露水平下,因遗传易感性的个体差异,不同人群的铅中毒损伤程度和临床症状不尽相同。该差异可能与δ-氨基乙酰丙酸脱水酶(Deltaaminolevulinic acid dehydratase,ALAD)、维生素D受体(Vitamin D receptor,VDR)、N-甲基D-天冬氨酸受体(N-methyl-Daspartate receptor,NMDAR)及多巴胺受体D2(Dopamine receptor D2,DRD2)等基因多态性有关。该文回顾近年来国内外铅神经毒性相关基因多态性的研究,对铅的神经毒性、相关基因多态性与铅神经毒性的关系进行综述。
|
| 关 键 词： | 铅 神经毒性 基因多态性 |
Gene polymorphism related with neurotoxic effects of lead: a review of recent studies |
| |
| SHEN Yuan,WU Xue-wen,SUN Hong.Gene polymorphism related with neurotoxic effects of lead: a review of recent studies[J].Journal of Environment and Health,2017,34(2). |
| |
| Authors: | SHEN Yuan WU Xue-wen SUN Hong |
| |
| Abstract: | Long-term lead exposure is hazardous to multiple organs and systems,especially the nervous system.The population who suffered the same dose of lead exposure presented different clinical symptoms.The lead-induced injure may due to individual hereditary susceptibility which probably related to polymorphism of delta-aminolevulinic acid dehydratase (ALAD)gene,vitamin D receptor(VDR) gene,N-methyl-D-aspartate receptor(NMDAR) gene or dopamine D2 receptor(DRD2) gene,etc.In this paper,the neurotoxicity of lead was reviewed and the relationship between lead neumtoxicity and polymorphism was summarized. |
| |
| Keywords: | Lead Neurotoxicity Gene polymorphism |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
