No evidence for pathogenic role of IgE in Henoch-Schoenlein purpura nephritis |
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Authors: | K Kano Tamotsu Ando Sachio Ito Keisho Kyo Yohko Ohwada |
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Institution: | (1) Department of Pediatrics, Dokkyo University School of Medicine, 880 Kitakobayashi Mibu, Shimotsuga, Tochigi 321-0293, Japan Tel +81-282-86-1111; Fax +81-282-86-7521, JP |
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Abstract: | Background. The incidence of increased plasma IgE levels was reported to be significantly higher in Henoch-Schoenlein purpura nephritis
(HSPN) than in IgA nephropathy (IgAN), and IgE deposits were demonstrated on epidermal Langerhans cells and dermal mast cells
in four of six patients with HSPN in two European studies. We designed this study to investigate whether levels of clinical
and biological markers of atopy in children with HSPN were significantly higher than those in children with IgAN, non-IgA
glomerulonephritis (non-IgAGN), or microhematuria.
Methods. The incidence of atopic disease, increased IgE levels, and positive radioallergosorbent test (RAST) results was investigated
in 28 children with HSPN, 26 with IgAN, 28 with non-IgAGN, and 30 with microhematuria, all aged 8–16 years. All patients except
for those in the microhematuria group, had proteinuria greater than100 mg/dl and had had a kidney biopsy.
Results. The incidence of atopic disease, increased IgE levels, and positive RAST results in children with HSPN did not differ from
findings in children with IgAN, non-IgAGN, or microhematuria.
Conclusion. Our results in Japanese children do not support the idea (suggested by the two European studies) that IgE may play an important
role in the pathogenesis of HSPN.
Received: February 9, 1998 / Accepted: July 3, 1998 |
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Keywords: | Atopy Henoch-Schoenlein purpura nephritis IgA nephropathy IgE RAST |
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