氯诺昔康用于妇科术后镇痛的效果观察

目的评价氯诺昔康用于妇科腹腔镜手术后镇痛的安全性、有效性以及不良反应。方法46例妇科择期行子宫（次）全切术以及附件手术患者随机分成氯诺昔康组（A组，n=23）和曲马朵组（B组，n=23）进行比较观察。所有患者均采用瑞芬太尼-丙泊酚全凭静脉麻醉，两组患者分别记录术后2、4、8、12、24h的VAS评分，患者镇痛满意度评分以及各种不良反应。结果A组术后2、4、8h时间VAS评分分别为（3．12±0．90）、（2．84±1．72）、（3．01±1．69），明显低于B组对应时间点VAS评分（P〈0．05）；镇痛满意度两组比较差异统计学意义（P〉0．05），B组PCIA期间恶心、呕吐发生率为30．4％、26．1％，明显高于A组（P〈0．05）。结论氯诺昔康静脉自控镇痛（PCA）用于妇科手术后镇痛效果确切、不良反应发生率低，值得临床推广应用。

The effects of post operative analgesia with lornoxicam on gynaecological operation patients

Objective To evaluate the analgesic efficiency and adverse effects of post operative patient-con-trolled intravenous analgesia(PCIA)with lornoxicam and tramadol in patients underwent gynaecologlcal operation.Methods 46 ASA(American Society of Anesthesiologists)Ⅰ-Ⅱ patients who undertook gynaecological operation were divided into two groups:lornoxicam group(group A,n=23)and tramadol group(group B,n=23).Each patient used remifentanil-propofol total intravenous anesthesia and received post-operation analgesia.We assessed the effectiveness by visual analogue scale(VAS)and analgesia satisfication degree at different time points:2,4,8,12 and 24 h after the beginning of analgesia were assessed.The analgesic efficacy of analgesia and the adverse effects during analgesia period were observed.Result The VAS scores of group A in 2,4,8 h were(3.12±0.90),(2.84±1.72)and(3.01±1.69),which were lower than those of group B(P<0.05).The incidences of nausea and vomiting in group A(30.4%and 26.1%)were significantly lower than those in group B(P<0.05)Conclusion Lornoxicam could provide an precise analgesic effect and lower adverse effect and worthy to be popularized.