| 纳洛酮在失血性休克复苏中与一氧化氮的关系 |
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| 引用本文： | 许琴,魏振宇,任伟,王箐.纳洛酮在失血性休克复苏中与一氧化氮的关系[J].遵义医学院学报,2010,33(6). |
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| 作者姓名： | 许琴 魏振宇 任伟 王箐 |
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| 作者单位： | 遵义医学院检验系,贵州遵义,563000 |
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| 摘 要： | 目的探讨纳络酮(NLX)在失血性休克复苏中的作用及对一氧化氮(NO)含量的影响。方法 建立失血性休克动物模型;实验分休克复苏生理盐水组(NS)﹑休克复苏纳洛酮处理组(NLX)两组;检测休克前后及复苏后血浆中NO的变化。结果与失血性休克前相比,NS和NLX组在失血性休克后血浆NO均增加(<0.01);失血休克复苏期,NLX组较NS组血浆NO含量显著降低(<0.05);NAL组存活时间(109.5±22.2)min显著长于NS组(60.8±14)min((<0.01)。结论 NLX延长动物休克模型的存活时间,可能是通过降低血浆NO水平而起作用的。
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| 关 键 词： | 纳洛酮 失血性休克 一氧化氮 |
The role of nitric oxide and the change of NO level on hemorrhagic shock |
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| XU Qin,WEI Zhen-Yu,REN Wei,WANG Qing.The role of nitric oxide and the change of NO level on hemorrhagic shock[J].Acta Academiae Medicine Zunyi,2010,33(6). |
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| Authors: | XU Qin WEI Zhen-Yu REN Wei WANG Qing |
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| Institution: | XU Qin; WEI Zhen-Yu; REN Wei; WANG Qing(The department of Caborary; Zunyi Medical College; 563000); |
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| Abstract: | Objective To explore the function of naloxone and to investigate the change of nitric oxide on hemorrhagic shock.Methods Hemorrhagic shock rabbits were prepared by withdrawing blood.Rabbits were divided in control group(NS)and naloxone treatmentgroup(NLX).Results The change of palsma NO levels of both groups were statistically significant higher after shock and resuscitation(P<0.01).Plasma NO concentration were significantly lower in the NAL treatment group than in the control group(P<0.01).The surviv... |
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| Keywords: | Nitric oxide Hemorrhagic shock Naloxone |
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