阿昔洛韦联合纳洛酮对病毒性脑炎患儿炎性因子及预后的影响

目的探讨阿昔洛韦联合纳洛酮对病毒性脑炎患儿炎性因子及预后的影响。方法选取2017年1月至2018年3月本院收治的病毒性脑炎患儿90例作为研究对象,依据盲抽法分为观察组与对照组,各45例。对照组采用阿昔洛韦治疗,观察组在对照组基础上利用纳洛酮治疗,比较两组炎症因子水平肿瘤坏死因子-α(TNF-α)、白细胞介素-1(IL-1)]、血清神经功能指标髓鞘碱性蛋白(MBP)、S-100β蛋白及神经元烯醇化酶(NSE)]及后遗症发生率。结果治疗后,两组TNF-α、IL-1水平均较治疗前降低,且观察组优于对照组,差异有统计学意义(P<0.05);治疗后,两组MBP、S-100β、NSE均较治疗前降低,且观察组低于对照组,差异有统计学意义(P<0.05);观察组后遗症发生率为6.67%,低于对照组的22.22%,差异有统计学意义(P<0.05)。结论阿昔洛韦与纳洛酮联合使用,可有效减轻病毒性脑炎患儿炎症反应及脑损伤,且预后效果显著,利于疾病转归。

Effects of acyclovir combined with naloxone on inflammatory factors and prognosis in patients with viral encephalitis

Objective To investigate the effect of acyclovir combined with naloxone on inflammatory factors and prognosis in patients with viral encephalitis.Methods 90 patients with viral encephalitis admitted to our hospital from January 2017 to March 2018 were selected as the research subjects.According to the blind drawing method,they were divided into observation group and control group,with 45 cases in each group.The control group was treated with acyclovir,and the observation group was treated with naloxone on the basis of the control group.Compare the levels of inflammatory factorstumor necrosis factor-α(TNF-α),interleukin-1(IL-1)],Serum nerve function indexesmyelin basic protein(MBP),S-100βprotein and neuron enolase(NSE)]and the incidence of sequelae.Results After treatment,TNF-α,IL-1 of the two groups is lower than before treatment,and the observation group was better than the control group,the difference was statistically significant(P<0.05);after treatment,MBP,S-100β,NSE in the two groups were lower than before treatment,and the observation group was lower than the control group,the difference was statistically significant(P<0.05);the incidence of sequelae in the observation group was 6.67%,which was lower than 22.22%in the control group,the difference was statistically significant(P<0.05).Conclusion Acyclovir combined with naloxone,it can effectively reduce inflammation and brain injury in patients with viral encephalitis,and the prognosis effect is significant.It is beneficial to the outcome of the disease.