C-反应蛋白和中性粒细胞淋巴细胞比值对系统性红斑狼疮疾病活动度评估的临床价值

目的探讨C-反应蛋白(CRP)和中性粒细胞淋巴细胞比值(NLR)对系统性红斑狼疮疾病(SLE)活动度评估的临床价值。方法选取2012年2月至2015年2月在本院接受治疗的110例系统性红斑狼疮疾病(SLE)患者作为实验组,选取同期健康体检者110名作为对照组。比较两组检测结果,并评价其与SLE活动度的相关性。依据SLE疾病活动评分指数(SLEDAI)将实验组分为两组:SLEDAI≥10为活动组(n=54);SLEDAI<10为缓解组(n=56)。根据患者是否合并感染,将实验组分为合并感染组(n=55)和未合并感染组(n=55)。结果实验组NLR高于对照组(P<0.05),活动组CRP与缓解组比较差异有统计学意义(P<0.05),活动组NLR、SLEDAI评分与缓解组比较差异有统计学意义(P<0.05);治疗后,活动组CRP、NLR和SLEDAI评分与治疗前比较均降低(P<0.05);合并感染组CRP水平明显高于未合并感染组,差异有统计学意义(P<0.05);合并感染组与未合并感染组NLR、SLEDAI评分比较差异无统计学意义。结论C-反应蛋白(CRP)可能与SLE疾病活动无关,但与SLE合并感染性疾病相关,NLR与SLE疾病活动有关,CRP和NLR可作为评估SLE疾病活动度的反映指标。

The clinical value of C-reactive protein and neutrophil lymphocyte ratio in assessing the activity of systemic lupus erythematosus

Objective To investigate the clinical value of C-reactive protein(CRP)and neutrophilic granulocyte lymphocyte ratio(NLR)in assessing the activity of systemic lupus erythematosus(SLE).Methods 110 patients with systemic lupus erythematosus(SLE)treated in our hospital from February 2012 to February 2015 were selected as the experimental group,select 110 healthy people during the same period as the control group.The difference between the two groups of test results were compare and evaluate its correlation with SLE activity.Patients in the experimental group were divided into two groups according to SLE disease score activity index(SLEDAI):SLEDAI≥10 was the active group(n=54);SLEDAI<10 was the remission group(n=56).According to whether the patients were co-infected or not,the experimental group was divided into two groups:co-infected group(n=55)and non-co-infected group(n=55).Results The NLR of the experimental group was higher than that of the control group(P<0.05),the CRP level of the active group was significantly higher than that of the remission group(P<0.05),and the NLR and SLEDAI levels of the active group were significantly higher than those of the remission group(P<0.05);after treatment,the CRP,NLR and SLEDAI scores of the active group were significantly lower than those before treatment(P<0.05);the CRP level of the combined infection group was significantly higher than that of the non infection group,the difference was statistically significant(P<0.05);there was no significant difference in NLR and SLEDAI scores between the two groups.Conclusion C-reactive protein(CRP)may not be related to SLE disease activity,but it is related to SLE infectious diseases.NLR is related to SLE disease activity,and CRP and NLR can be used as response indicators to evaluate SLE disease activity.