抗生素序贯疗法在儿童急性肠系膜淋巴结炎治疗中的应用及安全性分析

目的 探讨抗生素序贯疗法在儿童急性肠系膜淋巴结炎治疗中的应用及安全性分析.方法 选取2017年3月至2019年3月收治的100例儿童急性肠系膜淋巴结炎患儿作为研究对象,按随机抽签法分为对照组与研究组,每组50例.对照组采用抗生素全程静脉治疗方法,研究组采用抗生素序贯疗法.比较两组临床疗效,临床血液检查指标(PCT、白细...

Application and safety analysis of antibiotic sequential therapy in children with acute mesenteric lymphadenitis

Objective To explore the application and safety of sequential antibiotic therapy in the treatment of children with acute mesenteric lymphadenitis.Methods 100 children with acute mesenteric lymphadenitis in children who were admitted from March 2017 to March 2019 were selected as the research subjects,and they were divided into control group and study group according to random drawing method,with 50 cases in each group.The control group was treated with whole course intravenous antibiotic therapy,and the study group was treated with sequential antibiotic therapy.The clinical efficacy,clinical blood test indexes(PCT,WBC count,neutrophil percentage),clinical laboratory indexes(CD3^+,CD4^+,CD8^+,CD4^+/CD8^+)and adverse reactions(nausea and vomiting,loss of appetite,abdominal distension)were compared between the two groups.Results The total effective rate of treatment in the study group was higher than that in the control group(P<0.05).Before treatment,there was no statistically significant difference between the two groups of PCT,white blood cell count,and neutrophil percentage;after treatment,the two groups of PCT,white blood cell count,and neutrophil percentage were lower than before treatment,and the study group was lower than the control group(P<0.05).Before treatment,there was no significant difference between the two groups of CD3^+,CD4^+,CD8^+,CD4^+/CD8^+;after treatment,the CD3^+,CD4^+,CD4^+/CD8^+of two group were higher than before treatment,and CD8^+was lower than before treatment,and the CD3^+,CD4^+,CD4^+/CD8^+of study group were higher than the control group,and CD8^+was lower than the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups.Conclusion The application of antibiotic sequential therapy in the treatment of children with acute mesenteric lymphadenitis is safe and effective,which is worthy of clinical application.