| tSAH患者血清内皮素与神经元特异性烯醇化酶的动态检测 |
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| 引用本文： | 史建国,姜勇,董亚南,高军,孟雷,高松.tSAH患者血清内皮素与神经元特异性烯醇化酶的动态检测[J].中华神经外科疾病研究杂志,2008,7(1):4-6. |
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| 作者姓名： | 史建国 姜勇 董亚南 高军 孟雷 高松 |
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| 作者单位： | 济南市中心医院神经外科,山东,济南,250013 |
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| 摘 要： | 目的观察外伤性蛛网膜下腔出（tSAH）患者血清中内皮素-1（ET-1），神经元特异性烯醇化酶（NSE）水平的变化。方法用双抗体夹心酶标免疫分析法和放免法检测50例外伤性蛛网膜下腔出血患者发病24h内、第3、7、14d血清中ET、NSE的水平并与对照组比较。结果外伤性蛛网膜下腔出血患者血清中ET水平较正常对照组高（P〈0．01），第3、7d升高明显，第14d有降低但仍高于对照组，血清中NSE水平第7d达高峰。结论ET、NSE的变化可以反映蛛网膜下腔出后脑损伤程度。
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| 关 键 词： | 蛛网膜下腔出血 内皮素-1 神经元特异性烯醇化酶 |
| 文章编号： | 1671-2897（2008）07-004-03 |
| 收稿时间： | 2006-09-27 |
| 修稿时间： | 2007-04-10 |
Clinical study of serum ET and NSE levels in patients with traumatic subarachnoid hemorrhage |
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| SHI Jian-guo,JIANG Yong,DONG Ya-nan,GAO Jun,MENG Lei,GAO Song.Clinical study of serum ET and NSE levels in patients with traumatic subarachnoid hemorrhage[J].Chinese Journal of Neurosurgical Disease Research,2008,7(1):4-6. |
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| Authors: | SHI Jian-guo JIANG Yong DONG Ya-nan GAO Jun MENG Lei GAO Song |
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| Institution: | (Department of Neurosurgery, Jinan Central Hospital, Jinan 250013, China) |
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| Abstract: | Objective To study the serum endothelin-1 （ET-1） and neuronspecific enolase （NSE）levels in patient with traumatic subarachnoid hemorrhage （tSAH）. Methods The serum ET-1 and NSE levels at 1, 3, 7 and 14 d after onset of tSAH in 50 patients were detected by radio-immunediffusion and double antibody sandwich enzynre-tinked immunosorbent assay. Results The serum ET-1 and NSE levels in patients with tSAH were higher than that of the normal control （P 〈 0. 01 ）. The highest levels of ET appeared at 3 d and 7 d and NSE level reached the peak at 7 d. Conclusion The levels of ET-1 and NSE may reflect the brain damage degree after tSAH. |
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| Keywords: | Subarachnoid hemorrhage Endothelin-1 Neuronspecific enolase |
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