Pharmacological evidence of catecholaminergic involvement in the behavioral effects of luteinizing hormone releasing hormone in rats |
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| Authors: | S Mora G Diaz-Veliz |
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| Affiliation: | 1. Department of Medical Science, School of Veterinary Medicine, University of Wisconsin–Madison, Madison, WI 53706;2. Universidade Federal de Lavras, Faculdade de Zootecnia e Medicina Veterinária, Lavras, MG 37200-900, Brazil;1. Theriogenology Department, Faculty of Veterinary Medicine, Matrouh University, Matrouh 51512, Egypt;2. Animal and Fish Production Department, Faculty of Agriculture (El-Shatby), Alexandria University, Alexandria 21545, Egypt;1. School of Veterinary Science, University of Queensland, Gatton, 4343, Australia;2. Department of Large Animal Clinical Sciences, University of Saskatchewan, Saskatoon, S7N 5B4, Canada;3. Department of Agricultural Food and Nutritional Science, University of Alberta, Edmonton, T6G 2P5, Canada;1. Agrotecnio Centre, University of Lleida, 25198, Lleida, Spain;2. Transfer in Bovine Reproduction SLu, 22300, Barbastro, Spain;3. Department of Animal Science, University of Lleida, 25198, Lleida, Spain;1. Transplant Renal Medicine, Emory University School of Medicine, Atlanta, Georgia, USA;2. The University of Texas Health Science Center at San Antonio Joe R and Teresa Lozano Long School of Medicine, San Antonio, TX, USA;3. Division of Cardiology, The University of Texas Health at San Antonio, San Antonio, Texas, USA;4. Division of Nephrology, The University of Texas Health at San Antonio, San Antonio, Texas, USA;1. Clinic of Reproductive Medicine, Vetsuisse Faculty, University of Zurich, Switzerland;2. Department of Small Animal Clinical Sciences, Virginia-Maryland College of Veterinary Medicine, USA;3. Department of Obstetrics and Food Animal Medicine Clinic, University of Veterinary Medicine Budapest, Hungary;4. Institute of Veterinary Anatomy, Vetsuisse Faculty, University of Zurich, Switzerland;5. Department of Histology and Embryology, Faculty of Veterinary Medicine, Erciyes University, Turkey;6. Laboklin GmbH and Co. KG, Bad Kissingen, Germany;7. Department of Advanced Pathobiology, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Japan;8. ATRC Aurigon Ltd., Dunakeszi, Hungary;9. Clinic of Small Animal Surgery and Reproduction at the Centre for Clinical Veterinary Medicine, Faculty of Veterinary Medicine, Ludwig-Maximilians-University, Munich, Germany |
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| Abstract: | The influence of L-DOPA on the behavioral effects of LHRH was studied in male rats. Subcutaneous administration of LHRH (100 micrograms/kg) caused a significant disruption in the acquisition of a conditioned avoidance response (CAR) and a significant increase in head shaking behavior (HSB). Pretreatment with this hormone antagonized the stimulatory action of amphetamine (1 mg/kg, IP) in acquisition of CARs, spontaneous motor activity (SMA) and rearing behavior (RB). L-DOPA (100 mg/kg, IP), administered after LHRH, stimulated SMA, RB and HSB. In addition L-DOPA antagonized the effect of LHRH on acquisition of CARs and counteracted the antagonism between LHRH and amphetamine in acquisition of CARs and SMA. These findings indicate that LHRH could exert its behavioral effects through an inhibitory action upon brain catecholamine synthesis. The suppression of CARs may be the response to DA antagonism and the interaction with amphetamine could be mediated by an inhibition of both DA and NE activities. The possibility of an interaction between LHRH and central serotonin mechanisms is also discussed. |
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