葛根素穴位注射治疗早中期帕金森病:多中心随机对照试验

目的:观察葛根素注射液双侧风池穴位注射治疗早中期帕金森病的疗效。方法:使用随机数字表将135例早中期帕金森病患者分为穴位注射组、针刺组及西药组各45例。西药组给予复方左旋多巴每次125mg,每日2次口服治疗;穴位注射组在西药组的基础上给予葛根素注射液双侧风池穴位注射治疗;针刺组则在西药组的基础上给予双侧风池穴针刺治疗。各组均治疗8周。分别于治疗前后、1月随访时采用UPDRS量表进行病情评估,并进行总进步率评定。结果:治疗后穴位注射组、针刺组精神、行为和情绪状况评分均优于西药组(P0.05),穴位注射组与针刺组比较差异无统计学意义(P0.05);1月随访时穴位注射组明显优于西药组(P0.05)。治疗后日常活动能力改善方面,穴位注射组明显优于其余两组(P0.05);1月随访时穴位注射组仍具有优势(P0.05)。各组患者总进步率比较,差异无统计学意义(P0.05)。结论:葛根素穴位注射配合西药治疗早中期帕金森病患者可更好地改善精神、行为、情绪症状及日常活动能力。

Acupoint Injection of Kakkonein for Early-or Mid-stage Parkinson's Disease:A Multicenter Randomized Controlled Clinical Trial

Objective To investigate short-and long-term benefits and safety of acupoint injection of kakkonein for early-or mid-stage Parkinson's disease(PD).Methods A total of 135 patients with early-or mid-stage PD were enlisted and 116 cases completed the observation,including 40 cases in the acupoint-injection group,37 cases in the acupuncture group and 39 cases in the medication group.Patients of the acupoint-injection group were treated by injection of kakkonein(2mL)into bilateral Fengchi(GB 20),once very other day for 8weeks.For acupuncture intervention,bilateral GB 20 acupoints were punctured with filiform needles,once every other day for 8weeks.Patients of the medication group were treated by oral administration of compound levodopa(125mg/time,twice a day)for 8weeks.The disease severity was assessed by using Unified Parkinson's Disease Rating Scale(UPDRS,version 3.0)before and after treatment,and one month after the treatment.Results After the treatment,scores of psychosis,behavior and emotion,daily life activity and motor function were all significantly decreased in the three groups in comparison with pre-treatment in each group(P<0.05),suggesting an improvement of the PD patients' conditions.The therapeutic effect of acupoint-injection and acupuncture groups was markedly superior to that of the medication group(P<0.05).One-month's follow-up showed that the scores of behavior-emotion and daily life activity were obviously lower in the acupoint-injection group than in the acupuncture and medication groups(P<0.05).No significant differences were found between the acupuncture and medication groups in down-regulating scores of behavior-emotion,daily life activity and motor function(P>0.05).Conclusion Acupoint injection of kakkonein can improve patients' behavior,emotion,and daily life activity in early-or mid-stage PD patients and has both short-and longer-term benefits.