Abstract: | Objective To assess the effect of mannatide perfusion through minimal-trauma indwelling on improving quality of life (QOL)in malignant pleural or peritoneal effusions (MPPE) by EORTC-QLQ-C30(V3.0) Chinese version . Methods Between October 2003 and February 2008, the Mannatide injection perfusion through an indwelling central venous catheter was considered as a treatment possibility for 69 advanced cancer patients with MPPE presenting at our single department. All of the patients' performance statuses were hypo-function and the median Karuofsky performance status was 40 points. The questionnaire was administered at two points time of start treatment and one month weeks post-treatment. Results The standard score of functional scales in the physical ,emotion and global health and QOL functioning were statistically significant improver from 21.11±7.74,41.17±13.98 and 23.56±19.42 to 42.94±29.56,50.00±18.18 and 64.11±12.01 (P〈0.01 ,P〈0.05,P〈0.01 ),respectively. Their improvement rates were 71.01%,50.73% and 72.46%,respectively. The standard score of symptom scales and singleitems in fatigue, nausea and vomiting, pain, dyspnea, sleep disturbance and appetite loss were statistically significant degraded. Their improvement rates were 69.57%, 39.13%, 68.12%, 88.41%, 47.83% and 37.68%, respectively. The financial impact item standard score improvement rate was 2.09%. The response rates of the malignant effusion therapeutic effect was 86.96 %( 23 CR±37 PR/69). KPS score was statistically significant improver from 44.90±13.17 to 64.11±12.01 (P〈0.01). The KPS improvement rate was 78.26%. Conclusion Mannatide perfusion through Minimal-trauma indwelling central venous catheter could improve the QOL of advanced cancer patient with MPPE.It is a very safe, effective and useful technique for MPPE patients, particularly if system or region perfusion chemotherapy are not available. |