hs-CRP与GHbA1c、TG、CHO水平变化在糖尿病并发冠心病中的作用

目的探讨高敏C反应蛋白（hs-CRP）、糖化血红蛋白A1c（GHbA1c）、甘油三酯（TG）、胆固醇（CHO）水平变化在糖尿病（DM）并发冠心病发生、发展中的作用。方法比较38例糖尿病并发冠心病患者与93例糖尿病无并发症患者及106例健康对照者的血中hs-CRP、GHbA1c、TG、CHO水平的差异。结果单纯糖尿病患者hs-CRP较正常对照组明显升高,差异有统计学意义（P〈0.05）,糖尿病并发冠心病组的hs-CRP显著高于正常对照组,其差异均有高度统计学意义（P〈0.001）,且与单纯糖尿病组比较也明显增高,具有统计学意义（P〈0.05）。单纯糖尿病组和糖尿病并发冠心病组患者的HbA1c水平较正常对照组明显升高,差异有统计学意义（P〈0.05或P〈0.001）。结论检测糖尿病患者hs-CRP、HbA1c水平有利于监测其病情、评价疗效及预防糖尿病并发冠心病。

Application of hs-CRP、GHbA1c、TG and CHO as a reference to cases of diabetes mellitus complicated with coronary cardiopathy

Objective To investigate the changes of high sensitive C-reactive （hs-CRP）,glycosylated hemoglobin A1c （GHbA1c）,TG and CHO in the incidence and developement of diabetes （DM） complicated with coronary cardiopathy. Methods Comparations of the levels of hs-CRP,GHbA1c,TG and CHO were made in 38 cases of DM complicated with coronary cardiopathy,93 cases of DM without complication and 106 cases of healthy persons. Results The level of hs-CRP in DM without complication was higher than that of the contrast group obviously,the difference was of statistical significance（P〈0.05）. The level of hs-CRP in DM complicated with coronary cardiopathy was still higher than that of the contrast group. The difference was of highly statistic significance （P〈0.001）. It was also higher than that of the DM without complication and the difference was of statistical significance （P〈0.05）. The level of GHbA1c of simple DM and DM complication with coronary cardiopathy were higher than that of the contrast group obviously. And the differences were of statistical significance （P〈0.05 or P〈0.001）. Conclusion The examination of the level of hs-CRP and GHbA1c is clinically very important. It helps to supervise the developement of the disease,to estimate the therapeutic results and to prevent complication.