| 氧化苦参碱大鼠肠道吸收机理及吸收部位的研究 |
| |
| 引用本文： | 王素军,王广基,李晓天,杨敏,阮金秀,张振清. 氧化苦参碱大鼠肠道吸收机理及吸收部位的研究[J]. 中国临床药理学与治疗学, 2005, 10(12): 1326-1329 |
| |
| 作者姓名： | 王素军 王广基 李晓天 杨敏 阮金秀 张振清 |
| |
| 作者单位： | 1. 军事医学科学院毒物药物研究所药物代谢重点实验室,北京,100850
2. 中国药科大学药物代谢研究中心,南京,210038,江苏 |
| |
| 基金项目： | 国家863计划(№2003AA2Z347A，№2003AA2Z347B) |
| |
| 摘 要： | 目的探明氧化苦参碱在大鼠肠道各区段的吸收动力学特征、吸收部位及吸收机制,以期对药物长效缓释制剂的设计提供重要依据。方法采用大鼠在体肠灌流吸收实验,研究了氧化苦参碱的吸收部位和吸收动力学特征。结果氧化苦参碱在肠道的吸收呈现一级吸收动力学特征且吸收机制为被动转运。药物在小肠部位吸收良好,吸收速度按空肠、回肠、十二指肠、结肠的顺序依次下降,吸收速率常数依次为0.237、0.225、0.200和0.062h-1。结论氧化苦参碱的吸收窗比较长,适于制备缓释给药系统。
|
| 关 键 词： | 氧化苦参碱 大鼠 吸收部位 吸收机理 被动转运 |
| 文章编号： | 1009-2501(2005)12-1326-04 |
| 收稿时间： | 2005-09-24 |
| 修稿时间： | 2005-11-01 |
Absorption mechanism and absorption site of oxymatrine in rats |
| |
| WANG Su-jun,WANG Guang-ji,LI Xiao-tian,YANG Min,RUAN Jin-xiu,ZHANG Zhen-qing. Absorption mechanism and absorption site of oxymatrine in rats[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2005, 10(12): 1326-1329 |
| |
| Authors: | WANG Su-jun WANG Guang-ji LI Xiao-tian YANG Min RUAN Jin-xiu ZHANG Zhen-qing |
| |
| Affiliation: | Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Bering 100850, China ; 2 Key Lab of Drug Metabolism and Pharmacokinetics , China Pharmaceutical University, Nanjing 210038, Jiangsu , China |
| |
| Abstract: | AIM: To study the absorption mechanism and absorption site of oxymatrine in rats. METHODS: The absorption kinetics and absorption site of oxymatrine were investigated using in situ perfusion method in rats. RESULTS: The absorption mechanism of oxymatrine complied with the passive diffusion and first order kinetics. The absorption rate decreased according to the turn of jejunum, ileum, duodenum and colon. The absorption rate constants were 0.237 , 0.225 , 0.200 and 0.062 h -1 at jejunum, ileum, duodenum and colon, respectively. CONCLUSION: Oxymatrine can be prepared and processed into sustained-release dosages forms. |
| |
| Keywords: | oxymatrine rats absorption site absorption mechanism passive diffusion. |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
