Tumor doubling time and local immune response to hepatic metastases from colorectal cancer |
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Authors: | Kito Ayako Tanaka Kuniya Fujimaki Haruka Nakazawa Masatoshi Togo Shinji Minami Mutsuhiko Shimada Hiroshi |
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Affiliation: | Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Japan. kito427@yokohama-cu.ac.jp |
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Abstract: | BACKGROUND AND OBJECTIVES: A number of studies have investigated the role of tumor-infiltrating lymphocytes in cancer, yet the local immune response to hepatic colorectal cancer metastasis remains unclear. As the tumor doubling time (DT) of hepatic colorectal cancer metastases is a good index of tumor growth, we examined the correlation between tumor DT and the local immune response by phenotype in hepatic colorectal cancer metastases. METHODS: Tumor DT and local immune response were examined in 20 patients with hepatic colorectal cancer metastases by analyzing tumor-infiltrating lymphocytes using flow cytometry or immunohistochemical studies. Tumor proliferative activity was also investigated by determining the expression levels of Ki-67 and proliferating cell nuclear antigen (PCNA). RESULTS: Locally abundant populations of CD83(+) dendritic cells (DCs) and CD8(+) T cells were positively related to longer tumor DT (P < 0.05), as were abundant CD8(+) T cells having interferon-gamma-producing potentials (P < 0.05). There was no significant correlation between tumor cell expression levels of Ki-67 or PCNA and tumor DT. CONCLUSIONS: Longer DT tumors have increased local populations of CD8(+) T cells and CD83(+) DCs even in hepatic colorectal cancer metastases. |
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Keywords: | colorectal cancer liver metastasis tumor‐infiltrating lymphocytes dendritic cell tumor proliferation |
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