| 褪黑素对小鼠子宫内膜发育的影响 |
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| 引用本文： | 尼佳乐,纪春华,陈欢欢,王琳,汪艳丽,李银生.褪黑素对小鼠子宫内膜发育的影响[J].新乡医学院学报,2010,27(1):018-20. |
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| 作者姓名： | 尼佳乐 纪春华 陈欢欢 王琳 汪艳丽 李银生 |
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| 作者单位： | 新乡医学院公共卫生学系; 新乡医学院组织胚胎学教研室 |
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| 基金项目： | 新乡医学院大学生科技创新计划资助课题(2007) |
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| 摘 要： | 目的探讨褪黑素对小鼠子宫内膜发育的影响,为临床用药提供实验依据。方法随机将80只雌性昆明小鼠分为非受孕组和受孕组,每组又分为非喂药组和喂药组,每组20只。喂药组给予褪黑素,非喂药组给予生理盐水。于用药10 d后24 h内处死非受孕组小鼠,取子宫做成石蜡切片,苏木素-伊红(HE)染色,光镜观察并进行图像分析。在非受孕组雌鼠处死取材的当天,受孕组雌鼠与雄鼠合笼,于受孕后6 d处死受孕组小鼠,观察孕鼠着床情况,取子宫做成石蜡切片,HE染色,光镜观察并进行图像分析。结果非受孕组:喂药组子宫内膜厚度(157.21±0.09)μm明显薄于非喂药组(290.32±0.12)μm(P<0.05);2组子宫腺体的直径、周长比较无统计学意义(P>0.05)。受孕组:喂药组子宫内膜厚度(269.73±0.13)μm明显薄于非喂药组(368.35±0.19)μm(P<0.05),喂药组子宫腺体的直径、周长明显小于非喂药组(P<0.05)。结论褪黑素能够抑制小鼠子宫内膜的发育。
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| 关 键 词： | 褪黑素 子宫内膜 小鼠 发育 |
Effect of melatonin on development of endometrium in mice |
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| NI Jia-le,JI Chun-hua,CHEN Huan-huan,WANG Lin,WANG Yan-li,LI Yin-sheng.Effect of melatonin on development of endometrium in mice[J].Journal of Xinxiang Medical College,2010,27(1):018-20. |
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| Authors: | NI Jia-le JI Chun-hua CHEN Huan-huan WANG Lin WANG Yan-li LI Yin-sheng |
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| Abstract: | Objective To study the effect of melatonin on development of endometrium in mice in order to provide experimental basis for clinical medication.Methods Eighty female Kunming mice were randomly divided into non-pregnant group and pregnant group,each group was divided into non-treatment group and treatment group,twenty mice in each group.Each treatment group were given melatonin while in the non-treatment group received normal saline.After the drug was given for 10 days,the non-pregnant mice were sacrificed w... |
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| Keywords: | melatonin endometrium mice development |
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