Production of Specific Antisera to Human B Lymphocytes |
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| Authors: | Peter Goodfellow Colin Barnstable Elizabeth Jones Walter F. Bodmer Michael J. Crumpton David Snary |
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| Affiliation: | Genetics Laboratory, Department of Biochemistry, University of Oxford, Oxford;, England;National Institute for Medical Research, London, England |
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| Abstract: | Antisera have been prepared, in mice and rabbits, to membrane and sub-membrane fractions of human B lymphocyte derived lymphoid lines. Antisera to a protein subfraction were, after only minimal absorption, specific for human peripheral B lymphocytes, monocytes and B cell derived lymphoid lines. The antigen(s) recognised by these antisera were not the same as the previously described B-cell markers; immunoglobulin, Fc receptor, complement receptor and Ia antigens. The antigen(s) could not be removed from cells by lysostrip with anti- β2 microglobulin. |
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