The association of SULT1A1 codon 213 polymorphism and breast cancer susceptibility: meta-analysis from 16 studies involving 23,445 subjects |
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Authors: | Yiyi Sun Zhihe Zang Xiaohong Xu Zhonglin Zhang Ling Zhong Wang Zan Yan Zhao and Lin Sun |
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Institution: | (1) Chengdu Medical College, Chengdu, Sichuan Province, 610083, China;(2) West China Hospital, Sichuan University, Chengdu, Sichuan Province, 610041, China; |
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Abstract: | Epidemiological studies on the association between SULT1A1 codon 213 polymorphism and breast cancer risk are inconclusive.
In order to derive a more precise estimation of the association, a meta-analysis was conducted in this article. Sixteen studies
including 9,881 cases and 13,564 controls were collected for SULT1A1 codon 213 polymorphism by searching the databases of
Medline, PubMed, Embase, and ISI Web of Knowledge. The strength of association between SULT1A1 codon 213 polymorphism and
breast cancer susceptibility was assessed by calculating crude ORs with 95% CIs. When all the 21 studies were pooled into
the meta-analysis, there was no evidence for significant association between SULT1A1 codon 213 polymorphism and breast cancer
susceptibility (for Arg/Arg versus Arg/His: OR = 0.999, 95% CI = 0.941–1.061; for Arg/Arg versus His/His: OR = 1.121, 95%
CI = 1.013–1.242; for dominant model: OR = 1.128, 95% CI = 1.01–1.26; for recessive model: OR = 1.151, 95% CI = 0.950–1.394).
In the subgroup analysis by the source of controls, significant increased risk was found for hospital-based studies (for Arg/Arg
versus Arg/His: OR = 1.173, 95% CI = 1.000–1.376; for Arg/Arg versus His/His: OR = 1.600, 95% CI = 1.134–2.256; for dominant
model: OR = 1.269, 95% CI = 1.134–2.256; for recessive model: OR = 1.664, 95% CI = 1.070–2.588). In summary, the meta-analysis
suggests that SULT1A1 codon 213 polymorphism may be associated with the hospital-based studies. However, large number of samples
and representative hospital-based studies with homogeneous breast cancer patients and well-matched controls are warranted
to confirm this finding. |
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