| 应用meta分析方法研究肺纤维化TNF-α时空变化规律 |
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| 引用本文： | 高宏生,YANG Xia,兰晓霞,DING Peng,王世鑫. 应用meta分析方法研究肺纤维化TNF-α时空变化规律[J]. 武警医学院学报, 2008, 17(9): 721-726 |
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| 作者姓名： | 高宏生 YANG Xia 兰晓霞 DING Peng 王世鑫 |
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| 作者单位： | 1. 武警医学院天津市职业与环境危害生物标志物重点实验室,天津,300162;军事医学科学院卫生装备研究所,天津,300161
2. 武警医学院天津市职业与环境危害生物标志物重点实验室,天津,300162 |
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| 基金项目： | 天津市自然基金面上项目 |
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| 摘 要： | 【目的】探讨肺纤维化与TNF-α的时空变化规律。【方法】检索Cochrane图书馆、MEDLINE、CBM-disc等数据库，纳入18篇TNF-α与博来霉素诱导的肺纤维化文章进行meta分析。【结果】肺组织、肺巨噬细胞、血清内部各组总效应Z值（P值）分别为5．20（0.00001）、2．22（0.03）、0．91（0．36）。肺组织第1、3、7、14、21、28天总效应Z值（P值）分别为0．03（0．98）、3．85（0．0001）、5．18（0．00001）、5．37（0．00001）、2．39（0．02）、5．20（0．00001）。【结论】肺组织中TNF-α表达明显，血清中表达不明显，造模后第14天为肺纤维化TNF-α变化的明显拐点。
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| 关 键 词： | 肺纤维化 肿瘤坏死因子α Meta分析 |
Study on the space-time relation between levels of TNF-a and pulmonary fibrosis with meta-analysis |
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| GAO Hong-sheng,YANG Xia,LAN Xiao-xia,DING Peng,WANG Shi-xin. Study on the space-time relation between levels of TNF-a and pulmonary fibrosis with meta-analysis[J]. Acta Academiae Medicinae CPAPF, 2008, 17(9): 721-726 |
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| Authors: | GAO Hong-sheng YANG Xia LAN Xiao-xia DING Peng WANG Shi-xin |
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| Affiliation: | GAO Hong-sheng, YANG Xia, LAN Xiao-xia, DING Peng, WANG Shi-xin (Tianjin Key Laboratory of Occupational and Environmental Hazards Biomarkers, Medical College of Chinese People＇s Armed Police Force, Tianjin 300162,China) |
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| Abstract: | [Objective] To evaluate the space-time relationship between levels of TNF-α and pulmonary fibrosis. [Methods] A Meta-analysis of 18 studies on TNF-α and pulmonary fibrosis induced with bleomycin was performed with Cochrane Collaboration, Medline, CBMdisc and so on. [Results] Compared with the controls, overall effect Z vualue （ P value） on random effects model in pumanary tissue, macrophage and serum was 5.20 （0.00001）, 2.22 （0.03）, 0.91 （0.36）, respectively. And overall effect in the first , third, seventh, forteenth, twenty first, twenty eighth day after construction model was0.03 （0.98）, 3.85 （0.0001）, 5.18 （0.00001）, 5.37 （0.00001）, 2.39 （0.02）, 5.20 （0. 00001）, respectively. [Conclusions] Among pumanary tissue, macrophage and serum, levels of TNF-α in pumanary tissue was maximum, serum＇s was minimum. The inflection point of TNF-α in pumanary fibrosis formation was possibly in the fourteenth day. |
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| Keywords: | Pulmanary fibrosis TNF-α Metaanalysis |
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