两种颈淋结巴清扫术对口腔鳞癌cN_0期患者手术疗效比较:基于国内样本的Meta分析

目的:采用Meta分析方法,综合定量分析国内公开发表的有关国人cN0期口腔鳞癌患者行两种颈淋巴结清扫术的疗效,为cN0期患者颈淋巴结手术处理方式提供参考依据。方法:搜集国内所有公开发表的、随访资料完整、随机性良好的、分别采用肩胛舌骨上颈淋巴结清扫术(supraomohyoid neck dissection,SOND)与根治性颈淋结巴清扫术(radical neck dissection,RND)对cN0期患者手术疗效行对比观察的相关研究。对符合条件的资料行Meta分析,计算两组间淋巴结转移复发的比数比(odds ratio,OR)。结果:在88篇报道中,有6篇符合纳入标准。标本量1 065例,其中SOND组291例,阳性97例;RND组774例,阳性236例。OR=0.87<0.05(SOND/RND),95%CI为(0.60,1.26)。两者差异无统计学意义。结论:SOND与RND对cN0期口腔鳞癌患者的手术疗效无明显差异,SOND可取代RND以提高患者生存质量。

Comparison of surgical effects on two kinds of neck dissection in patients with oral cavity squamous cell carcinoma in cN_0 stage:a Meta analysis based on the sample in China

Objective: To compare the surgical effect of two kinds of neck dissection in the Chinese patients with oral cavity squamous cell carcinoma in cN_0 stage using the Meta analysis in order to provide some reference for cN_0 patients.Methods: All randomized controlled researches from China about the surgical effect of the supraomohyoid neck dissection(SOND) and radical neck dissection(RND) were looked through.Odds ratio was calculated between the two groups.Results: Six researches was adopted among the 88 reports.The total number of sample was 1065.The number of test group was 291,in which 97 were positive;of control group was 774,in which 236 were positive.OR was(0.87<)0.05(SOND/RND) and 95%CI was(0.60,1.26).There was no significantly statistical difference between the two groups. Conclusions: SOND and RND have similar effect in treatment of oral cavity squamous cell carcinoma cN_0 stage,therefore it is better to use SOND to improve the life quality of the patients.