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| 葛心通缓释片体外释放度的研究 | |
| 引用本文： | 李雪平,程岚,白景义,马秀军,韩宏伟. 葛心通缓释片体外释放度的研究[J]. 辽宁中医杂志, 2008, 35(3): 430-431 |
| 作者姓名： | 李雪平 程岚 白景义 马秀军 韩宏伟 |
| 作者单位： | 1. 辽宁中医药大学药学院,辽宁,大连,116600 2. 沈阳医药股份有限公司,辽宁,沈阳,110002 3. 辽宁天士力医药有限公司,辽宁,沈阳,110000 |
| 摘 要： | 目的:确定葛心通缓释片的体外释放度的测定方法及其体外释放度。方法:采用转篮法,考察不同溶出介质中葛根素的释放情况,选择合适的溶出介质;确定最佳的转速,采用HPLC法测定葛心通缓释片的累积释放度,确定制剂的体外药物释放度。结果:以蒸馏水为溶出介质,葛心通缓释片在100 r/min的条件下,在2、6、12h的释放度分别为30%~40%、65%~75%、90%~98%。结论:葛心通缓释片体外释放度符合药典要求,具有良好的缓释行为。 |
| 关 键 词： | 缓释 葛根素 体外释放度 |
| 文章编号： | 1000-1719(2008)03-0430-02 |
| 修稿时间： | 2007-10-11 |
A Study on in Vitro Release Rate of Gexintong Sustained Released Tablets |
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| LI Xue-ping,CHENG Lan,BAI Jing-yi,MA Xiu-jun,HAN Hong-wei. A Study on in Vitro Release Rate of Gexintong Sustained Released Tablets[J]. Liaoning Journal of Traditional Chinese Medicine, 2008, 35(3): 430-431 | |
| Authors: | LI Xue-ping CHENG Lan BAI Jing-yi MA Xiu-jun HAN Hong-wei |
| Abstract: | Objective:To establish the method and the in vitro release rate of gexintong sustained tablets.Methods:A reverse phase HPLC method was developed to determine the release rate of the preparation.Dissolution media and the rotating speed were optimized by comparing the release of puerarin.Result:The release rate of the preparation at 2、6、12h is30%～40%、65%～75%、90%～98% in distilled water at the rotating speed 100r/min.Conclusion: In vitro release rate of Gexintong sustained released tablets is appropriate and meet Chinese pharmacopeia requirments. |
| Keywords: | sustained release puerarin in vitro release rate |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |