| 氧化修饰低密度脂蛋白对血管内皮依赖性舒张的影响 |
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| 引用本文： | 陈立,刘冰,杨翰仪.氧化修饰低密度脂蛋白对血管内皮依赖性舒张的影响[J].吉林大学学报(医学版),1999,25(5):2. |
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| 作者姓名： | 陈立 刘冰 杨翰仪 |
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| 作者单位： | 1. 基础医学院生化教研室,长春,130021
2. 第一临床医院血库 |
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| 摘 要： | 目的：探讨氧化修饰低密度脂蛋白（ Ｏｘ Ｌ Ｄ Ｌ）中溶血性卵磷脂（ Ｌ Ｐ Ｃ）与血管效应的关系。方法：采用 Ｃｕ２＋ 对低密度脂蛋白进行氧化修饰，测定 Ｏｘ Ｌ Ｄ Ｌ 的磷脂含量及其对血管舒张的影响。结果： Ｏｘ Ｌ Ｄ Ｌ 中的 Ｌ Ｐ Ｃ 量增加，卵磷脂（ Ｐ Ｃ）量减少。 Ｏｘ Ｌ Ｄ Ｌ 明显抑制血管内皮依赖性舒张，且抑制强度与 Ｌ Ｐ Ｃ量呈正相关。结论： Ｏｘ Ｌ Ｄ Ｌ 对血管舒张的抑制作用与 Ｌ Ｐ Ｃ 有关。
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| 关 键 词： | 低密度脂蛋白 氧化修饰 溶血性卵磷脂 血管舒张 |
| 修稿时间： | 1998-11-03 |
Effect of oxidized low-density lipoprotein on endothelium-dependent vasorelaxation |
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| Chen Li,Liu Bing,Yang Hanyi.Effect of oxidized low-density lipoprotein on endothelium-dependent vasorelaxation[J].Journal of Jilin University: Med Ed,1999,25(5):2. |
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| Authors: | Chen Li Liu Bing Yang Hanyi |
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| Abstract: | Objective:To study relationship between LPC (lysophosphatidylcholine) of oxidized LDL (low density lipoprotein) and impairment of endothelium dependent vasorelaxation.Methods:LDL was oxidatively modified by Cu 2+ at 37℃.Phospholipids were measured.Endothelium dependent vasorelaxation was investigated.Results:Oxidized LDL significantly increased LPC and decreased PC contents.Oxidized LDL produced impairment of endothelium dependent vasorelaxation in rat aortic rings.LDL with higher LPC contents had greater impairment endothelium dependent vasorelaxation than LDL with lower LPC contents.Conclusion:Impairment of endothelium dependent vasorelaxation produced by oxidized LDL is related to amount of LPC. |
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| Keywords: | oxidized low density lipoprotein LPC endothelium dependent vasorelaxation |
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