Anti-leishmania activity of semi-purified fraction of <Emphasis Type="Italic">Jacaranda puberula</Emphasis> leaves |
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| Authors: | L F D Passero A A Castro T Y Tomokane M J Kato T F Paulinetti C E P Corbett M D Laurenti |
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| Institution: | 1.Departamento de Patologia, Faculdade de Medicina,Universidade de S?o Paulo (USP),Cerqueira César, S?o Paulo,Brazil;2.Departamento de Bioquímica, Instituto de Química,Universidade de S?o Paulo (USP),Butant?, S?o Paulo,Brazil |
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| Abstract: | The crude methanolic extract from leaves of Jacaranda puberula showed activity against Leishmania (Leishmania) amazonensis. The extract presented active against promastigote forms with an inhibitory concentration 50% (IC50) value of 88.0 μg/ml, but only moderated activity against amastigote forms; however in higher concentrations the extract
showed cytotoxic effects. The bio-guided chromatographic fractionation the crude methanolic extract against amastigotes yielded
a fraction with an IC50 value of 14.0 μg/ml (without cytotoxic activity) in relation to the crude extract (IC50 value, 359.0 μg/ml). These data indicate that J. puberula leaves contain active compounds, which should be further investigated for the development of new potential drugs against
cutaneous leishmaniasis. |
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