| 藤茶双氢杨梅树皮素对人肝癌BEL-7404细胞增殖的抑制作用 |
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| 引用本文： | 郑作文,唐云丽,张玉萌. 藤茶双氢杨梅树皮素对人肝癌BEL-7404细胞增殖的抑制作用[J]. 中国药物应用与监测, 2008, 5(1): 4-6 |
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| 作者姓名： | 郑作文 唐云丽 张玉萌 |
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| 作者单位： | 广西中医学院,南宁,530001 |
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| 摘 要： | 目的：探讨藤茶双氢杨梅树皮素（APS）的抗肿瘤作用。方法：以MTT法、生长曲线法、克隆形成法观察APS对人肝癌BEL-7404细胞的体外抑制作用。结果：MTT法中，APS对BEL-7404细胞的IC50为22．99μg／mL；细胞生长曲线法提示其对BEL-7404细胞生长有明显抑制作用；克隆形成法中，药物浓度在9．88μg／mL以上时抑制率为100％，药物浓度为6．58μg／mL时抑制率为69．65％。结论：APS对BEL-7404细胞的增殖有明显的抑制作用。
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| 关 键 词： | 藤茶双氢杨梅树皮素 抗肿瘤 人肝癌BEL-7404细胞 |
| 文章编号： | 1672-8157(2008)01-0004-03 |
| 修稿时间： | 2007-01-09 |
Inhibition effect of ampelopsin on proliferation of BEL-7404 human liver cancer cell |
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| ZHENG Zuo-wen,TANG Yun-li,ZHANG Yu-meng. Inhibition effect of ampelopsin on proliferation of BEL-7404 human liver cancer cell[J]. , 2008, 5(1): 4-6 |
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| Authors: | ZHENG Zuo-wen TANG Yun-li ZHANG Yu-meng |
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| Affiliation: | ZHENG Zuo-wen,TANG Yun-li,ZHANG Yu-meng(1.Guangxi Traditional Chinese Medical University, Nanning, 530001; 2.Graduate Student of Guangxi Traditional Chinese Medical University, Nanning, 530001) |
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| Abstract: | Objective：To investigate the anti-tumor effect of ampelopsin in vitro.Methods：The growth inhibition was analyzed by MTT, cell colony and cell growth curve measurement in the liver carcinoma BEL-7404.Results：The ampelopsin could obviously inhibit the growth of cultured BEL-7404 cells, the IC50 in MTr assay is 22.99μg/mL; Ampelopsin could obviouly affect on the tumor cells＇growth; The repressive ratio in cell colony assay is 100% when medicine density is over 9.88μg/mL, the repressive ratio in cell colony assay is 69.65% when medicine density is 6.58μg/mL.Conclusion：Ampelopsin can inhibit the growth of BEL-7404 in vitro. |
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| Keywords: | Ampelopsin Anti-tumor BEL-7404 human liver cancer cell |
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